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Tbio
PSMD5
26S proteasome non-ATPase regulatory subunit 5

Protein Summary
Description
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000210313
  • ENSP00000210313
  • ENSG00000095261
  • ENST00000373904
  • ENSP00000363011

Symbol
  • KIAA0072
  • S5B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
histone modification site profile
0.91
kinase perturbation
0.88
transcription factor perturbation
0.8
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1158.73   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1158.73   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (222)
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
p_int:  0.99967861
p_ni:  0.00032139
Score:  0.998
Data Source:  BioPlex,STRINGDB
PSMD10
Tbio
Family:  Enzyme
Novelty:  0.01331382
p_int:  0.999645201
p_ni:  0.000354799
Score:  0.99
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.99823124
p_ni:  8.23e-7
p_wrong:  0.001767937
Data Source:  BioPlex
PSMD1
Tbio
Family:  Enzyme
Novelty:  0.02168311
p_int:  0.998182263
p_ni:  0.001817737
Score:  0.99
Data Source:  BioPlex,STRINGDB
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.996491989
p_ni:  0.003508011
Score:  0.984
Data Source:  BioPlex,STRINGDB
PSMC6
Tbio
Family:  Enzyme
Novelty:  0.00168013
p_int:  0.994522989
p_ni:  0.005477011
Score:  0.987
Data Source:  BioPlex,STRINGDB
PSMC2
Tbio
Family:  Enzyme
Novelty:  0.08240664
p_int:  0.993957128
p_ni:  0.006042872
Score:  0.995
Data Source:  BioPlex,STRINGDB
PSMC1
Tbio
Family:  Enzyme
Novelty:  0.04631888
p_int:  0.992519357
p_ni:  0.007480643
Score:  0.99
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.990237402
p_ni:  0.009762598
Score:  0.985
Data Source:  BioPlex,STRINGDB
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.987586229
p_ni:  0.012413771
Score:  0.99
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (154)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
89.1
birth weight
4
3
4
77.8
5
4
2
1.1
77.7
serum non-albumin protein measurement
1
1
1
64
myeloid white cell count
1
1
1
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
89.1
birth weight
4
77.8
2
1.1
77.7
serum non-albumin protein measurement
1
64
myeloid white cell count
1
60.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 5
VGNC:9190
464699
Macaque
proteasome 26S subunit, non-ATPase 5
700827
Mouse
MGI:1914248
66998
Rat
RGD:1308434
296651
Dog
proteasome 26S subunit, non-ATPase 5
474703
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 5
Macaque
proteasome 26S subunit, non-ATPase 5
Mouse
Rat
Dog
proteasome 26S subunit, non-ATPase 5
Publication Statistics
PubMed Score 1158.73
PubMed score by year
PubTator Score 8.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title