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Tbio
PSMD4
26S proteasome non-ATPase regulatory subunit 4

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368884
  • ENSP00000357879
  • ENSG00000159352

Symbol
  • MCB1
  • AF
  • ASF
  • S5A
  • AF-1
  • MCB1
  • Rpn10
  • pUB-R5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
biological process
0.98
hub protein
0.96
interacting protein
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.81   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 406   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.81   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 406   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (439)
UBE3A
Tbio
Family:  Enzyme
Novelty:  0.00149368
p_int:  0.999999194
p_ni:  8.06e-7
Score:  0.683
Data Source:  BioPlex,STRINGDB
PSMD5
Tbio
Family:  Enzyme
Novelty:  0.00070666
p_int:  0.99967861
p_ni:  0.00032139
Score:  0.998
Data Source:  BioPlex,STRINGDB
GGA1
Tbio
Novelty:  0.00866392
p_int:  0.999321862
p_ni:  0.00067786
p_wrong:  2.78e-7
Data Source:  BioPlex
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
p_int:  0.999237526
p_ni:  0.000762474
Score:  0.999
Data Source:  BioPlex,STRINGDB
ADRM1
Tbio
Novelty:  0.01545209
p_int:  0.999024756
p_ni:  0.000975244
Score:  0.999
Data Source:  BioPlex,STRINGDB
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.998239612
p_ni:  0.001760389
Data Source:  BioPlex
CCDC74B
Tdark
Novelty:  1.7435743
p_int:  0.99735411
p_ni:  0.00264589
Score:  0.816
Data Source:  BioPlex,STRINGDB
PSMD10
Tbio
Family:  Enzyme
Novelty:  0.01331382
p_int:  0.997325543
p_ni:  0.002674457
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD1
Tbio
Family:  Enzyme
Novelty:  0.02168311
p_int:  0.992412388
p_ni:  0.007587612
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.990014736
p_ni:  0.009985264
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (159)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
33.3
78.9
1
1
0
100
76.6
vitamin D measurement
1
1
1
59
lymphocyte count
1
1
1
29
Ischemic stroke
1
1
0
12.5
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
33.3
78.9
0
100
76.6
vitamin D measurement
1
59
lymphocyte count
1
29
Ischemic stroke
0
12.5
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 4
VGNC:9885
100192399
Mouse
MGI:1201670
19185
Rat
RGD:621109
83499
Dog
proteasome 26S subunit, non-ATPase 4
VGNC:45113
100192385
Cow
proteasome 26S subunit, non-ATPase 4
VGNC:33468
282016
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 4
Mouse
Rat
Dog
proteasome 26S subunit, non-ATPase 4
Cow
proteasome 26S subunit, non-ATPase 4
Publication Statistics
PubMed Score 160.81
PubMed score by year
PubTator Score 84.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title