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Tbio
PSMD3
26S proteasome non-ATPase regulatory subunit 3

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264639
  • ENSP00000264639
  • ENSG00000108344

Symbol
  • S3
  • P58
  • RPN3
  • TSTA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
transcription factor binding site profile
0.94
hub protein
0.9
histone modification site profile
0.89
virus perturbation
0.88


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.27   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.27   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (317)
MYH11
Tbio
Novelty:  0.00142474
p_int:  0.999999222
p_ni:  7.77e-7
Data Source:  BioPlex
DES
Tbio
Novelty:  0.00651741
p_int:  0.999996874
p_ni:  0.000003126
Data Source:  BioPlex
MYL9
Tbio
Novelty:  0.00309239
p_int:  0.999996526
p_ni:  4e-9
p_wrong:  0.000003469
Data Source:  BioPlex
PSMD7
Tbio
Family:  Enzyme
Novelty:  0.03090292
p_int:  0.999192752
p_ni:  0.000807248
Score:  0.999
Data Source:  BioPlex,STRINGDB
TAGLN
Tbio
Novelty:  0.00243855
p_int:  0.998462548
p_ni:  1.3e-8
p_wrong:  0.001537439
Data Source:  BioPlex
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.979304428
p_ni:  0.020695572
Score:  0.999
Data Source:  BioPlex,STRINGDB
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.971124857
p_ni:  0.028875143
Data Source:  BioPlex
MYH7
Tbio
Novelty:  0.00268092
p_int:  0.967566092
p_ni:  0.032433618
p_wrong:  2.89e-7
Data Source:  BioPlex
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.957385878
p_ni:  0.042614122
p_wrong:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
CCDC74B
Tdark
Novelty:  1.7435743
p_int:  0.956253341
p_ni:  0.043746659
Score:  0.816
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (159)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 149
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (62)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
11
14
22
99.9
leukocyte count
11
14
28
99.8
myeloid white cell count
5
7
7
99.6
childhood onset asthma
4
6
0
1.3
99.3
15
16
1
1.2
99.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
22
99.9
leukocyte count
28
99.8
myeloid white cell count
7
99.6
childhood onset asthma
0
1.3
99.3
1
1.2
99.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 3
VGNC:9544
454640
Macaque
proteasome 26S subunit, non-ATPase 3
698712
Mouse
MGI:98858
22123
Rat
RGD:1311470
287670
Dog
proteasome 26S subunit, non-ATPase 3
VGNC:45112
491018
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 3
Macaque
proteasome 26S subunit, non-ATPase 3
Mouse
Rat
Dog
proteasome 26S subunit, non-ATPase 3
Publication Statistics
PubMed Score 31.27
PubMed score by year
PubTator Score 9.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title