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Tchem
PSMD14
26S proteasome non-ATPase regulatory subunit 14

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. This gene encodes a component of the 26S proteasome. The 26S prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409682
  • ENSP00000386541
  • ENSG00000115233

Symbol
  • POH1
  • PAD1
  • POH1
  • RPN11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
disease perturbation
0.98
virus perturbation
0.94
kinase perturbation
0.88
histone modification site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.5   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.5   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (21)
SID85176685
Rendered image for SID85176685
CHEMBL4104719
Rendered image for CHEMBL4104719
CHEMBL4095913,CHEMBL4091693
Rendered image for CHEMBL4095913,CHEMBL4091693
SID14741605
Rendered image for SID14741605
CHEMBL4100384
Rendered image for CHEMBL4100384
CHEMBL4073553
Rendered image for CHEMBL4073553
CHEMBL4070821
Rendered image for CHEMBL4070821
CHEMBL4093962
Rendered image for CHEMBL4093962
SID24782345
Rendered image for SID24782345
Protein-Protein Interactions (469)
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.999840792
p_ni:  0.000159208
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD7
Tbio
Family:  Enzyme
Novelty:  0.03090292
p_int:  0.999801119
p_ni:  0.000198881
Score:  0.999
Data Source:  BioPlex,STRINGDB
ADRM1
Tbio
Novelty:  0.01545209
p_int:  0.998458053
p_ni:  0.001541947
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
p_int:  0.995919231
p_ni:  0.004080769
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.99589754
p_ni:  0.00410246
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.989732342
p_ni:  0.010267658
Score:  0.995
Data Source:  BioPlex,STRINGDB
CCDC74B
Tdark
Novelty:  1.7435743
p_int:  0.982132616
p_ni:  0.017867384
Score:  0.828
Data Source:  BioPlex,STRINGDB
UCHL5
Tbio
Family:  Enzyme
Novelty:  0.01486265
p_int:  0.981180863
p_ni:  0.018819137
Score:  0.998
Data Source:  BioPlex,STRINGDB
PSMD10
Tbio
Family:  Enzyme
Novelty:  0.01331382
p_int:  0.97877975
p_ni:  0.02122025
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCDC92
Tbio
Novelty:  0.32125749
p_int:  0.972474309
p_ni:  0.027525691
Score:  0.828
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (190)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 150
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
3
4
6.5
94.4
mathematical ability
4
2
5
91.2
cognitive function measurement
3
2
4
88.2
intelligence
4
5
2
6
86.9
smoking status measurement
2
1
2
74.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
6.5
94.4
mathematical ability
5
91.2
cognitive function measurement
4
88.2
intelligence
2
6
86.9
smoking status measurement
2
74.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 14
VGNC:2791
459686
Macaque
proteasome 26S subunit, non-ATPase 14
701063
Mouse
MGI:1913284
59029
Rat
RGD:1594532
311078
Dog
proteasome 26S subunit, non-ATPase 14
VGNC:45110
478765
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 14
Macaque
proteasome 26S subunit, non-ATPase 14
Mouse
Rat
Dog
proteasome 26S subunit, non-ATPase 14
Publication Statistics
PubMed Score 113.50
PubMed score by year
PubTator Score 44.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title