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Tbio
PSMD13
26S proteasome non-ATPase regulatory subunit 13

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431206
  • ENSP00000396937
  • ENSG00000185627
  • ENST00000532097
  • ENSP00000436186

Symbol
  • S11
  • Rpn9
  • p40.5
  • HSPC027
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
biological process
0.98
disease perturbation
0.96
histone modification site profile
0.92
transcription factor perturbation
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.04   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.04   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (268)
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.999904277
p_ni:  0.000095723
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD11
Tbio
Family:  Enzyme
Novelty:  0.02148951
p_int:  0.999617614
p_ni:  0.000382386
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD1
Tbio
Family:  Enzyme
Novelty:  0.02168311
p_int:  0.999580829
p_ni:  0.000419171
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
p_int:  0.999237526
p_ni:  0.000762474
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD7
Tbio
Family:  Enzyme
Novelty:  0.03090292
p_int:  0.99919119
p_ni:  0.000808811
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD6
Tbio
Family:  Enzyme
Novelty:  0.04419339
p_int:  0.999132868
p_ni:  0.000867132
Score:  0.999
Data Source:  BioPlex,STRINGDB
RGPD5
Tbio
Novelty:  0.13776125
p_int:  0.998435122
p_ni:  0.001564878
Data Source:  BioPlex
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.996924349
p_ni:  0.003075651
Score:  0.996
Data Source:  BioPlex,STRINGDB
ADRM1
Tbio
Novelty:  0.01545209
p_int:  0.996668963
p_ni:  0.003331038
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD14
Tchem
Family:  Enzyme
Novelty:  0.01019285
p_int:  0.995919231
p_ni:  0.004080769
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (169)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 149
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (47)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
7
10
99.6
platelet count
5
5
5
4.7
98.9
alkaline phosphatase measurement
3
3
3
17.9
96.7
eosinophil count
3
3
4
96.7
eosinophil percentage of leukocytes
2
4
4
96.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
10
99.6
platelet count
5
4.7
98.9
alkaline phosphatase measurement
3
17.9
96.7
eosinophil count
4
96.7
eosinophil percentage of leukocytes
4
96.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 13
VGNC:8274
450913
Mouse
MGI:1345192
23997
Rat
RGD:1305236
365388
Dog
proteasome 26S subunit, non-ATPase 13
VGNC:45109
475934
Horse
proteasome 26S subunit, non-ATPase 13
VGNC:21959
100050948
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 13
Mouse
Rat
Dog
proteasome 26S subunit, non-ATPase 13
Horse
proteasome 26S subunit, non-ATPase 13
Publication Statistics
PubMed Score 21.04
PubMed score by year
PubTator Score 6.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title