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Tbio
PSMD10
26S proteasome non-ATPase regulatory subunit 10

Protein Summary
Description
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217958
  • ENSP00000217958
  • ENSG00000101843
  • ENST00000361815
  • ENSP00000354906

Symbol
  • p28
  • p28(GANK)
  • dJ889N15.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
histone modification site profile
0.85
transcription factor perturbation
0.84
virus perturbation
0.83
pathway
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.6   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 396   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.6   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 396   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (272)
ADRM1
Tbio
Novelty:  0.01545209
p_int:  0.999724386
p_ni:  0.000275614
Score:  0.995
Data Source:  BioPlex,STRINGDB
PSMD5
Tbio
Family:  Enzyme
Novelty:  0.00070666
p_int:  0.999645201
p_ni:  0.000354799
Score:  0.99
Data Source:  BioPlex,STRINGDB
PAAF1
Tbio
Family:  Enzyme
Novelty:  0.03229774
p_int:  0.9993912
p_ni:  0.0006088
Score:  0.981
Data Source:  BioPlex,STRINGDB
UCHL5
Tbio
Family:  Enzyme
Novelty:  0.01486265
p_int:  0.999161214
p_ni:  0.000838786
Score:  0.988
Data Source:  BioPlex,STRINGDB
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
p_int:  0.997325543
p_ni:  0.002674457
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
p_int:  0.995743269
p_ni:  0.004256731
Score:  0.999
Data Source:  BioPlex,STRINGDB
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.994688621
p_ni:  0.005311379
Data Source:  BioPlex
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.994129343
p_ni:  0.005870658
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCDC92
Tbio
Novelty:  0.32125749
p_int:  0.993476318
p_ni:  0.006523682
Score:  0.825
Data Source:  BioPlex,STRINGDB
PSMD1
Tbio
Family:  Enzyme
Novelty:  0.02168311
p_int:  0.992414778
p_ni:  0.007585222
Score:  0.998
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (154)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 10
VGNC:14711
465803
Macaque
proteasome 26S subunit, non-ATPase 10
703596
Mouse
MGI:1858898
53380
Rat
RGD:620350
116722
Dog
proteasome 26S subunit, non-ATPase 10
VGNC:45106
481014
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 10
Macaque
proteasome 26S subunit, non-ATPase 10
Mouse
Rat
Dog
proteasome 26S subunit, non-ATPase 10
Publication Statistics
PubMed Score 112.60
PubMed score by year
PubTator Score 94.71
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title