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Tchem
PSMC4
26S proteasome regulatory subunit 6B

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000157812
  • ENSP00000157812
  • ENSG00000013275
  • ENST00000455878
  • ENSP00000413869
  • ENST00000629691
  • ENSP00000487367
  • ENSG00000281221
  • ENST00000630857
  • ENSP00000485851

Symbol
  • MIP224
  • TBP7
  • S6
  • RPT3
  • TBP7
  • TBP-7
  • MIP224
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
biological process
0.98
kinase perturbation
0.97
histone modification site profile
0.92
molecular function
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.32   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.32   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (442)
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.999994768
p_ni:  0.000005232
Score:  0.999
Data Source:  BioPlex,STRINGDB
PAAF1
Tbio
Family:  Enzyme
Novelty:  0.03229774
p_int:  0.999757077
p_ni:  0.000242923
Score:  0.979
Data Source:  BioPlex,STRINGDB
GPAM
Tbio
Family:  Enzyme
Novelty:  0.00973127
p_int:  0.999514365
p_ni:  0.00005178
p_wrong:  0.000433855
Score:  0.161
Data Source:  BioPlex,STRINGDB
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.99879678
p_ni:  0.00120322
Score:  0.999
Data Source:  BioPlex,STRINGDB
ADRM1
Tbio
Novelty:  0.01545209
p_int:  0.998691864
p_ni:  0.001308136
Score:  0.999
Data Source:  BioPlex,STRINGDB
MYO1D
Tbio
Novelty:  0.03263543
p_int:  0.997515327
p_ni:  0.002484673
Data Source:  BioPlex
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
p_int:  0.993454892
p_ni:  0.006545108
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCDC74B
Tdark
Novelty:  1.7435743
p_int:  0.992733968
p_ni:  0.007266032
Score:  0.817
Data Source:  BioPlex,STRINGDB
PSMD7
Tbio
Family:  Enzyme
Novelty:  0.03090292
p_int:  0.992459397
p_ni:  0.007540603
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.991471704
p_ni:  0.008528296
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (160)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, ATPase 4
VGNC:14752
737578
Macaque
proteasome 26S subunit, ATPase 4
699847
Mouse
MGI:1346093
23996
Rat
RGD:621102
117262
Dog
proteasome 26S subunit, ATPase 4
VGNC:45104
100855613
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, ATPase 4
Macaque
proteasome 26S subunit, ATPase 4
Mouse
Rat
Dog
proteasome 26S subunit, ATPase 4
Publication Statistics
PubMed Score 57.32
PubMed score by year
PubTator Score 27.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title