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Tchem
PSMB9
Proteasome subunit beta type-9

Protein Summary
Description
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374859
  • ENSP00000363993
  • ENSG00000240065
  • ENST00000383114
  • ENSP00000372595
  • ENSG00000240118
  • ENST00000383234
  • ENSP00000372721
  • ENSG00000243594
  • ENST00000422729
  • ENSP00000407233
  • ENSG00000243067
  • ENST00000427870
  • ENSP00000412027
  • ENSG00000242711
  • ENST00000434471
  • ENSP00000393744
  • ENSG00000243958
  • ENST00000444284
  • ENSP00000396813
  • ENSG00000239836
  • ENST00000453059
  • ENSP00000407810
  • ENSG00000240508

Symbol
  • LMP2
  • PSMB6i
  • RING12
  • LMP2
  • PRAAS3
  • PSMB6i
  • RING12
  • beta1i
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
virus perturbation
0.99
biological process
0.98
PubMedID
0.91
transcription factor perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 731.04   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 731.04   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1