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Tdark
PSMA8
Proteasome subunit alpha-type 8

Protein Summary
Description
Component of the spermatoproteasome, a form of the proteasome specifically found in testis that promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308268
  • ENSP00000311121
  • ENSG00000154611
  • ENST00000343848
  • ENSP00000345584
  • ENST00000415576
  • ENSP00000409284

Symbol
  • PSMA7L
  • PSMA7L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
cell type or tissue
0.85
virus perturbation
0.72
pathway
0.66
gene perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.66   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.66   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (231)
PSMB1
Tclin
Family:  Enzyme
Novelty:  0.0255917
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMB4
Tbio
Family:  Enzyme
Novelty:  0.0376233
p_int:  0.999999997
p_ni:  1e-9
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMB7
Tbio
Family:  Enzyme
Novelty:  0.06547657
p_int:  0.999999994
p_ni:  5e-9
p_wrong:  2e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.999999992
p_ni:  7e-9
p_wrong:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
PSMB3
Tbio
Family:  Enzyme
Novelty:  0.12791198
p_int:  0.999999937
p_ni:  6.3e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
Score:  0.999
Data Source:  STRINGDB
PSMB5
Tclin
Family:  Enzyme
Novelty:  0.01864909
Score:  0.999
Data Source:  STRINGDB
PSMC2
Tbio
Family:  Enzyme
Novelty:  0.08240664
Score:  0.999
Data Source:  STRINGDB
PSMD6
Tbio
Family:  Enzyme
Novelty:  0.04419339
Score:  0.999
Data Source:  STRINGDB
PSMA1
Tclin
Family:  Enzyme
Novelty:  0.013722
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (139)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 137
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
56
testosterone measurement
1
1
0
1.1
46.2
C-reactive protein measurement
2
2
2
42.8
red blood cell density measurement
1
1
1
41.5
basophil count
1
1
1
30.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
56
testosterone measurement
0
1.1
46.2
C-reactive protein measurement
2
42.8
red blood cell density measurement
1
41.5
basophil count
1
30.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome subunit alpha 8
VGNC:5198
468505
Mouse
MGI:1920927
73677
Rat
RGD:1311659
364814
Dog
proteasome subunit alpha 8
VGNC:45093
100856395
Horse
proteasome subunit alpha 8
VGNC:21938
100064417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome subunit alpha 8
Mouse
Rat
Dog
proteasome subunit alpha 8
Horse
proteasome subunit alpha 8
Publication Statistics
PubMed Score 3.66
PubMed score by year
PubTator Score 0.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title