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Tdark
PSKH2
Serine/threonine-protein kinase H2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276616
  • ENSP00000276616
  • ENSG00000147613
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
protein domain
0.73
cell line
0.59
cell type or tissue
0.51
tissue sample
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.35   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.35   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
HSP90AA5P
Tdark
p_int:  0.999923601
p_ni:  0.000076398
p_wrong:  1e-9
Data Source:  BioPlex
HSP90AA4P
Tdark
p_int:  0.999859361
p_ni:  0.000140628
p_wrong:  1.1e-8
Data Source:  BioPlex
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.999840731
p_ni:  0.000159269
Score:  0.206
Data Source:  BioPlex,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.994372707
p_ni:  0.005627293
Data Source:  BioPlex
UNC119
Tchem
Novelty:  0.00396292
p_int:  0.935187777
p_ni:  0.064812223
Score:  0.535
Data Source:  BioPlex,STRINGDB
CDC37
Tbio
Novelty:  0.03730196
p_int:  0.907814646
p_ni:  0.092185354
Score:  0.288
Data Source:  BioPlex,STRINGDB
HSP90AB1
Tchem
Novelty:  0.00907961
p_int:  0.904558015
p_ni:  0.095441985
Score:  0.239
Data Source:  BioPlex,STRINGDB
UNC119B
Tbio
Novelty:  0.26468307
p_int:  0.837807911
p_ni:  0.162192089
Score:  0.87
Data Source:  BioPlex,STRINGDB
FAM169B
Tdark
Novelty:  4.63859648
Score:  0.584
Data Source:  STRINGDB
TMEM178A
Tdark
Novelty:  0.78925677
Score:  0.514
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
2
2
87.8
neutrophil count
2
2
2
68.5
myeloid white cell count
1
1
1
45.7
cognitive function measurement
1
1
1
17.8
self reported educational attainment
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
87.8
neutrophil count
2
68.5
myeloid white cell count
1
45.7
cognitive function measurement
1
17.8
self reported educational attainment
1
7.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein serine kinase H2
VGNC:815
464268
Dog
protein serine kinase H2
VGNC:45089
487033
Opossum
protein serine kinase H2
100029035
Platypus
protein serine kinase H2 [Source:HGNC Symbol;Acc:HGNC:18997]
C. elegans
171688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein serine kinase H2
Dog
protein serine kinase H2
Opossum
protein serine kinase H2
Platypus
protein serine kinase H2 [Source:HGNC Symbol;Acc:HGNC:18997]
C. elegans
Publication Statistics
PubMed Score 0.35
PubMed score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title