Tdark PSG8 Pregnancy-specific beta-1-glycoprotein 8

Protein Summary

Description

The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

Uniprot Accession IDs

• Q9UQ74
• A5PKV3
• B2RPL4
• B4DTI6
• O60410
• Q68CR6
• PS-beta-G-8

Gene Name

• PSG8

Ensembl ID

• ENST00000306511
• ENSP00000305005
• ENSG00000124467
• ENST00000404209
• ENSP00000385869
• ENST00000406636
• ENSP00000385081

Symbol

• PSG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
microRNA	0.59
cell line	0.55
tissue sample	0.36
disease	0.34

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.57   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 10   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.57   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (43)

Explore Interacting Targets

1 – 10 of 43

• See Interactions on String-DB

PSG1

Tbio

Novelty:  0.0239046

p_int:  0.999999998

p_ni:  1e-9

p_wrong:  2e-9

Score:  0.75

Data Source:  BioPlex,STRINGDB

CELSR3

Tbio

Family:  GPCR

Novelty:  0.02705624

p_int:  0.999996916

p_ni:  0.00000306

p_wrong:  2.4e-8

Data Source:  BioPlex

PSG4

Tbio

Novelty:  0.09464871

p_int:  0.999996641

p_ni:  8.3e-8

p_wrong:  0.000003276

Score:  0.621

Data Source:  BioPlex,STRINGDB

MCM9

Tbio

Family:  Enzyme

Novelty:  0.0390791

p_int:  0.999979088

p_ni:  0.00002091

p_wrong:  2e-9

Score:  0.2

Data Source:  BioPlex,STRINGDB

PEX7

Tbio

Novelty:  0.01487923

p_int:  0.99997416

p_ni:  0.000025836

p_wrong:  4e-9

Data Source:  BioPlex

TUBB1

Tclin

Novelty:  0.02806117

p_int:  0.999900664

p_ni:  0.000099335

p_wrong:  1e-9

Data Source:  BioPlex

GFM2

Tbio

Novelty:  0.02945848

p_int:  0.999887262

p_ni:  0.000112736

p_wrong:  2e-9

Data Source:  BioPlex

CBWD3

Tdark

Novelty:  0.03639787

p_int:  0.999606563

p_ni:  0.000393405

p_wrong:  3.2e-8

Data Source:  BioPlex

ACOT9

Tbio

Family:  Enzyme

Novelty:  0.17405187

p_int:  0.999383687

p_ni:  0.000616313

Data Source:  BioPlex

RHOBTB1

Tbio

Novelty:  0.02152609

p_int:  0.999011775

p_ni:  0.000161671

p_wrong:  0.000826554

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

Reactome (2)

Cell surface interactions at the vascular wall (R-HSA-202733)

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5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Hemostasis	666 targets	R-HSA-109582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Components (1)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
extracellular region	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
birth weight	EFO_0004344	1	1	1		31.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
birth weight	EFO_0004344	1		31.4

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Polymorphism
Reference proteome
Repeat
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
birth weight

IDG Resources

No IDG generated resources found

Orthologs

No orthologs found

Publication Statistics

PubMed Score 6.57

PubMed score by year

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PubTator Score 1.09

PubTator score by year

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Related Publications

Text Mined References (7)

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10

0 of 0

PMID	Year	Title