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Tbio
PSG3
Pregnancy-specific beta-1-glycoprotein 3

Protein Summary
Description
The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327495
  • ENSP00000332215
  • ENSG00000221826
  • ENST00000614582
  • ENSP00000480223
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell line
0.68
microRNA
0.52
co-expressed gene
0.4
tissue
0.38


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.48   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.48   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (18)
PSG1
Tbio
Novelty:  0.0239046
p_int:  0.999998856
p_ni:  0.000001143
Score:  0.883
Data Source:  BioPlex,STRINGDB
PSG9
Tbio
Novelty:  0.0426075
p_int:  0.999998413
p_ni:  4.4e-7
p_wrong:  0.000001147
Score:  0.873
Data Source:  BioPlex,STRINGDB
TMPRSS11A
Tbio
Family:  Enzyme
Novelty:  0.06142295
p_int:  0.999551875
p_ni:  0.000150215
p_wrong:  0.00029791
Score:  0.299
Data Source:  BioPlex,STRINGDB
ANKRD46
Tbio
Novelty:  0.06546845
p_int:  0.948246161
p_ni:  0.051613674
p_wrong:  0.000140165
Score:  0.813
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
Score:  0.917
Data Source:  STRINGDB
SDC3
Tbio
Novelty:  0.01095269
Score:  0.9
Data Source:  STRINGDB
GPC1
Tbio
Novelty:  0.00293087
Score:  0.9
Data Source:  STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.9
Data Source:  STRINGDB
TGFB1
Tbio
Novelty:  0.0001299
Score:  0.9
Data Source:  STRINGDB
SDC1
Tbio
Novelty:  0.00044792
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Cell surface interactions at the vascular wall (R-HSA-202733)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 14.48
PubMed score by year
PubTator Score 7.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title