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Tbio
PSG1
Pregnancy-specific beta-1-glycoprotein 1

Protein Summary
Description
The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244296
  • ENSP00000244296
  • ENSG00000231924
  • ENST00000312439
  • ENSP00000308970
  • ENST00000436291
  • ENSP00000413041
  • ENST00000595356
  • ENSP00000472610

Symbol
  • B1G1
  • PSBG1
  • PSGGA
  • SP1
  • B1G1
  • PBG1
  • CD66f
  • PSBG1
  • PSG95
  • PSGGA
  • DHFRP2
  • PSBG-1
  • PSGIIA
  • FL-NCA-1/2
  • PS-beta-C/D
  • PS-beta-G-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
microRNA
0.99
protein domain
0.73
cell line
0.65
virus perturbation
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.25   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.25   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
PSG4
Tbio
Novelty:  0.09464871
p_int:  1
Score:  0.863
Data Source:  BioPlex,STRINGDB
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.999999998
p_ni:  1e-9
p_wrong:  2e-9
Score:  0.75
Data Source:  BioPlex,STRINGDB
PSG3
Tbio
Novelty:  0.05846466
p_int:  0.999998856
p_ni:  0.000001143
Score:  0.883
Data Source:  BioPlex,STRINGDB
IKBKB
Tchem
Family:  Kinase
Novelty:  0.00090202
p_int:  0.999997657
p_ni:  0.000002343
Score:  0.622
Data Source:  BioPlex,STRINGDB
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
p_int:  0.999997541
p_ni:  0.000002412
p_wrong:  4.7e-8
Score:  0.518
Data Source:  BioPlex,STRINGDB
PSG9
Tbio
Novelty:  0.0426075
p_int:  0.999977745
p_ni:  0.000022209
p_wrong:  4.6e-8
Score:  0.542
Data Source:  BioPlex,STRINGDB
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999958038
p_ni:  0.000041962
Data Source:  BioPlex
CELSR3
Tbio
Family:  GPCR
Novelty:  0.02705624
p_int:  0.999683941
p_ni:  0.00029865
p_wrong:  0.00001741
Score:  0.539
Data Source:  BioPlex,STRINGDB
KLHL25
Tbio
Novelty:  0.14475787
p_int:  0.999157262
p_ni:  0.000238465
p_wrong:  0.000604274
Score:  0.173
Data Source:  BioPlex,STRINGDB
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.998646134
p_ni:  0.001353866
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Cell surface interactions at the vascular wall (R-HSA-202733)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
31.4
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 44.25
PubMed score by year
PubTator Score 30.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title