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Tbio
PSD3
PH and SEC7 domain-containing protein 3

Protein Summary
Description
Guanine nucleotide exchange factor for ARF6.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286485
  • ENSP00000286485
  • ENSG00000156011
  • ENST00000327040
  • ENSP00000324127
  • ENST00000440756
  • ENSP00000401704

Symbol
  • EFA6D
  • EFA6R
  • HCA67
  • KIAA0942
  • EFA6D
  • EFA6R
  • HCA67
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
virus perturbation
0.92
PubMedID
0.79
microRNA
0.75
phenotype
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.8   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.8   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
Score:  0.734
Data Source:  STRINGDB
KCTD4
Tdark
Novelty:  2.1757288
Score:  0.682
Data Source:  STRINGDB
SERPINI1
Tbio
Novelty:  0.00518205
Score:  0.542
Data Source:  STRINGDB
PNRC2
Tbio
Novelty:  0.08731548
Score:  0.509
Data Source:  STRINGDB
ZNF844
Tdark
Family:  TF
Novelty:  12.1910828
Score:  0.497
Data Source:  STRINGDB
IL1RAPL2
Tbio
Novelty:  0.13104919
Score:  0.486
Data Source:  STRINGDB
CHP2
Tbio
Novelty:  0.15598265
Score:  0.447
Data Source:  STRINGDB
SCHIP1
Tbio
Novelty:  0.0765945
Score:  0.445
Data Source:  STRINGDB
CFAP77
Tdark
Novelty:  4.08287895
Score:  0.441
Data Source:  STRINGDB
SCML1
Tdark
Novelty:  0.60106322
Score:  0.42
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
52.7
2
2
0
1.1
39.4
mean platelet volume
3
2
3
30.2
testosterone measurement
1
1
1
15.8
sleep duration
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
52.7
0
1.1
39.4
mean platelet volume
3
30.2
testosterone measurement
1
15.8
sleep duration
1
4.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 25.80
PubMed score by year
PubTator Score 14.56
PubTator score by year
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Related Publications
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PMID
Year
Title