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Tbio
PSCA
Prostate stem cell antigen

Protein Summary
Description
May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301258
  • ENSP00000301258
  • ENSG00000167653

Symbol
  • PRO232
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
biological term
0.68
transcription factor binding site profile
0.59
cell line
0.52
disease perturbation
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.1   (req: < 5)
Gene RIFs: 96   (req: <= 3)
Antibodies: 351   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.1   (req: >= 5)
Gene RIFs: 96   (req: > 3)
Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (187)
GLT8D2
Tbio
Family:  Enzyme
Novelty:  0.79488367
p_int:  0.999958753
p_ni:  0.000040889
p_wrong:  3.58e-7
Data Source:  BioPlex
SLC44A5
Tdark
Family:  Transporter
Novelty:  0.15262166
p_int:  0.999936645
p_ni:  0.000057121
p_wrong:  0.000006234
Data Source:  BioPlex
GALNT18
Tbio
Family:  Enzyme
Novelty:  0.15496205
p_int:  0.999815479
p_ni:  0.000184517
p_wrong:  4e-9
Data Source:  BioPlex
SLC44A1
Tbio
Family:  Transporter
Novelty:  0.01499456
p_int:  0.999604477
p_ni:  0.000384292
p_wrong:  0.000011231
Data Source:  BioPlex
ADAMTS2
Tbio
Family:  Enzyme
Novelty:  0.00852208
p_int:  0.999351524
p_ni:  0.000648476
Data Source:  BioPlex
SUSD1
Tdark
Novelty:  0.54249826
p_int:  0.999345552
p_ni:  0.000654412
p_wrong:  3.6e-8
Data Source:  BioPlex
TRPM7
Tchem
Family:  IC
Novelty:  0.00265096
p_int:  0.998873269
p_ni:  0.001125543
p_wrong:  0.000001187
Data Source:  BioPlex
ITGA8
Tbio
Novelty:  0.0220023
p_int:  0.998541494
p_ni:  0.001458506
Data Source:  BioPlex
NFE2L3
Tbio
Family:  TF
Novelty:  0.03576754
p_int:  0.998472776
p_ni:  2.9e-8
p_wrong:  0.001527195
Data Source:  BioPlex
SELENON
Tbio
Novelty:  0.01018
p_int:  0.99812863
p_ni:  0.001871369
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.3
92.4
pepsinogen I/II ratio
1
3
3
89.8
1
1
0
1.4
80.9
2
2
2
70.4
3
2
0
1.1
60.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.3
92.4
pepsinogen I/II ratio
3
89.8
0
1.4
80.9
2
70.4
0
1.1
60.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostate stem cell antigen
VGNC:816
472876
Mouse
MGI:1919623
72373
Rat
RGD:1594221
680210
Dog
prostate stem cell antigen
482068
Cow
prostate stem cell antigen [Source:HGNC Symbol;Acc:HGNC:9500]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostate stem cell antigen
Mouse
Rat
Dog
prostate stem cell antigen
Cow
prostate stem cell antigen [Source:HGNC Symbol;Acc:HGNC:9500]
Publication Statistics
PubMed Score 368.10
PubMed score by year
PubTator Score 176.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title