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Tdark
PRXL2C
Peroxiredoxin-like 2C

Protein Summary
Description
May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375234
  • ENSP00000364382
  • ENSG00000158122

Symbol
  • AAED1
  • C9orf21
  • AAED1
  • C9orf21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
cellular component
0.75
transcription factor perturbation
0.68
tissue sample
0.59
cell type or tissue
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.85   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.85   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0