Protein Summary
May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis.
- ENST00000375234
- ENSP00000364382
- ENSG00000158122
- AAED1
- C9orf21
- AAED1
- C9orf21
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.88 | ||
cellular component | 0.75 | ||
transcription factor perturbation | 0.68 | ||
tissue sample | 0.59 | ||
cell type or tissue | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.85 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 36 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.85 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 36 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0