Tdark PRXL2B Prostamide/prostaglandin F synthase

Protein Summary

Description

Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).

Uniprot Accession IDs

• Q8TBF2
• A8K793
• B3KPY3
• B4DQR9
• B4E0S5
• B7ZAC8
• B9DI90
• B9DI92
• J3KQD0
• Q8N2H0
• Prostamide/PG F synthase

Gene Name

• PRXL2B

Ensembl ID

• ENST00000378424
• ENSP00000367681
• ENSG00000157870
• ENST00000378427
• ENSP00000367684
• ENST00000419916
• ENSP00000394405

Symbol

• C1orf93
• FAM213B
• C1orf93
• FAM213B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.74
histone modification site profile	0.73
cellular component	0.7
tissue	0.68
small molecule perturbation	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.73   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.73   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0