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Tchem
PRXL2A
Peroxiredoxin-like 2A

Protein Summary
Description
Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372181
  • ENSP00000361254
  • ENSG00000122378
  • ENST00000372185
  • ENSP00000361259
  • ENST00000372187
  • ENSP00000361261
  • ENST00000372188
  • ENSP00000361262
  • ENST00000606162
  • ENSP00000482445
  • ENST00000615554
  • ENSP00000478152

Symbol
  • C10orf58
  • FAM213A
  • PAMM
  • Adrx
  • PAMM
  • FAM213A
  • C10orf58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
histone modification site profile
0.91
small molecule perturbation
0.88
transcription factor binding site profile
0.76
tissue sample
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.18   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.18   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1