You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PRUNE2
Protein prune homolog 2

Protein Summary
Description
May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376718
  • ENSP00000365908
  • ENSG00000106772

Symbol
  • BMCC1
  • BNIPXL
  • C9orf65
  • KIAA0367
  • BMCC1
  • BNIPXL
  • C9orf65
  • KIAA0367
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
transcription factor perturbation
0.84
microRNA
0.77
kinase perturbation
0.76
trait
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.24   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.24   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
ZMYM1
Tdark
Novelty:  0.3860445
p_int:  0.999884192
p_ni:  0.000115808
Score:  0.243
Data Source:  BioPlex,STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
p_int:  0.999872437
p_ni:  0.000127563
Score:  0.818
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.999820003
p_ni:  0.000179993
p_wrong:  3e-9
Score:  0.678
Data Source:  BioPlex,STRINGDB
YES1
Tclin
Family:  Kinase
Novelty:  0.00534936
p_int:  0.980434455
p_ni:  0.019565545
Score:  0.792
Data Source:  BioPlex,STRINGDB
TTPA
Tchem
Novelty:  0.003507
Score:  0.748
Data Source:  STRINGDB
AKAP13
Tbio
Family:  Enzyme
Novelty:  0.00726267
Score:  0.657
Data Source:  STRINGDB
SPTY2D1
Tdark
Novelty:  0.75211025
Score:  0.64
Data Source:  STRINGDB
IMMP2L
Tbio
Family:  Enzyme
Novelty:  0.03566408
Score:  0.577
Data Source:  STRINGDB
KIAA0895
Tdark
Novelty:  16.98666667
Score:  0.563
Data Source:  STRINGDB
KIF24
Tbio
Novelty:  0.13497665
Score:  0.557
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
81.3
myeloid white cell count
1
1
1
61
leukocyte count
1
1
1
56.2
1
1
1
45.7
dentures
2
1
2
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
81.3
myeloid white cell count
1
61
leukocyte count
1
56.2
1
45.7
dentures
2
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prune homolog 2
VGNC:14392
464537
Macaque
prune homolog 2
707402
Mouse
MGI:1925004
353211
Dog
prune homolog 2
VGNC:45078
484157
Horse
prune homolog 2
VGNC:49392
100063534
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prune homolog 2
Macaque
prune homolog 2
Mouse
Dog
prune homolog 2
Horse
prune homolog 2
Publication Statistics
PubMed Score 24.24
PubMed score by year
PubTator Score 10.71
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title