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Tchem
PRUNE1
Exopolyphosphatase PRUNE1

Protein Summary
Description
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271620
  • ENSP00000271620
  • ENSG00000143363
  • ENST00000368934
  • ENSP00000357930
  • ENST00000368935
  • ENSP00000357931
  • ENST00000368936
  • ENSP00000357932
  • ENST00000368937
  • ENSP00000357933

Symbol
  • PRUNE
  • PRUNE
  • DRES17
  • HTCD37
  • NMIHBA
  • DRES-17
  • H-PRUNE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.19   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.19   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (47)
SCGB1D4
Tdark
Novelty:  0.15597658
p_int:  0.999998415
p_ni:  0.000001585
Data Source:  BioPlex
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.999998145
p_ni:  0.000001855
Score:  0.51
Data Source:  BioPlex,STRINGDB
BORCS7
Tbio
Novelty:  0.14135922
p_int:  0.999984889
p_ni:  0.000015111
Data Source:  BioPlex
INSYN2
Tdark
Novelty:  2.55244594
p_int:  0.999943881
p_ni:  0.000056119
Data Source:  BioPlex
CCL22
Tbio
Novelty:  0.00245992
p_int:  0.99975395
p_ni:  0.00024605
Data Source:  BioPlex
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.999535437
p_ni:  0.000464528
p_wrong:  3.5e-8
Score:  0.212
Data Source:  BioPlex,STRINGDB
PIANP
Tbio
Novelty:  0.01739512
p_int:  0.999473279
p_ni:  0.000526721
Score:  0.189
Data Source:  BioPlex,STRINGDB
GMFG
Tbio
Novelty:  0.0893982
p_int:  0.999339566
p_ni:  0.000660434
Score:  0.34
Data Source:  BioPlex,STRINGDB
GMPPB
Tbio
Family:  Enzyme
Novelty:  0.05106206
p_int:  0.998164019
p_ni:  0.001778771
p_wrong:  0.00005721
Score:  0.529
Data Source:  BioPlex,STRINGDB
NPAS1
Tbio
Family:  TF
Novelty:  0.08014425
p_int:  0.990548757
p_ni:  0.009429855
p_wrong:  0.000021387
Score:  0.163
Data Source:  BioPlex,STRINGDB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
4
7
9.2
96.2
apolipoprotein A 1 measurement
2
3
3
95.6
sex hormone-binding globulin measurement
6
2
6
89.7
creatinine measurement
4
4
5
88.9
high density lipoprotein cholesterol measurement
3
2
3
85
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
9.2
96.2
apolipoprotein A 1 measurement
3
95.6
sex hormone-binding globulin measurement
6
89.7
creatinine measurement
5
88.9
high density lipoprotein cholesterol measurement
3
85
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
prune exopolyphosphatase 1
708898
Mouse
MGI:1925152
229589
Rat
RGD:1359521
310664
Dog
prune exopolyphosphatase 1
VGNC:45077
483189
Horse
prune exopolyphosphatase 1
VGNC:21925
100055127
Species
Name
OMA
EggNOG
Inparanoid
Macaque
prune exopolyphosphatase 1
Mouse
Rat
Dog
prune exopolyphosphatase 1
Horse
prune exopolyphosphatase 1
Publication Statistics
PubMed Score 49.19
PubMed score by year
PubTator Score 11.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title