Protein Summary
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).
- ENST00000234347
- ENSP00000234347
- ENSG00000196415
- ENST00000612112
- ENSP00000478977
- ENSG00000277804
- MBN
- MBN
- MBT
- NP4
- P29
- PR3
- ACPA
- AGP7
- NP-4
- PR-3
- CANCA
- C-ANCA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 0.81 | ||
gene perturbation | 0.81 | ||
cellular component | 0.8 | ||
cell type or tissue | 0.76 | ||
disease | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4704.34 (req: < 5)
Gene RIFs: 102 (req: <= 3)
Antibodies: 478 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4704.34 (req: >= 5)
Gene RIFs: 102 (req: > 3)
Antibodies: 478 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 19
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (19)
Protein-Protein Interactions (203)
XIAP
Family: Enzyme
Novelty: 0.00062268
p_int: 0.999956852
p_ni: 0.000043148
Data Source: BioPlex
GOLIM4
Novelty: 0.01923513
p_int: 0.999747494
p_ni: 0.000252505
p_wrong: 1e-9
Data Source: BioPlex
SERPINB1
Family: Enzyme
Novelty: 0.00267786
p_int: 0.981843281
p_ni: 0.017744273
p_wrong: 0.000412446
Score: 0.755
Data Source: BioPlex,STRINGDB
RAB3GAP1
Family: Enzyme
Novelty: 0.0286836
p_int: 0.978256955
p_ni: 0.021743012
p_wrong: 3.3e-8
Data Source: BioPlex
SPCS1
Family: Enzyme
Novelty: 0.0731223
p_int: 0.976080227
p_ni: 0.005873529
p_wrong: 0.018046244
Data Source: BioPlex
BIRC2
Novelty: 0.00199701
p_int: 0.941731489
p_ni: 0.058268472
p_wrong: 3.8e-8
Data Source: BioPlex
QRICH1
Novelty: 0.27714699
p_int: 0.88343682
p_ni: 0.114446273
p_wrong: 0.002116907
Data Source: BioPlex
SPCS2
Family: Enzyme
Novelty: 0.21358992
p_int: 0.859166522
p_ni: 0.140833478
Data Source: BioPlex
DHPS
Family: Enzyme
Novelty: 0.00776893
p_int: 0.834817607
p_ni: 0.165181977
p_wrong: 4.16e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (11)
Reactome (10)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Antimicrobial peptides | ||||
Reactome | Common Pathway of Fibrin Clot Formation | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Antimicrobial peptides | ||||
Common Pathway of Fibrin Clot Formation | ||||
Cytokine Signaling in Immune system | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (4)
Components (7)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 13 | 20 | 99.5 | |||||
reticulocyte count | 7 | 10 | 28 | 99.3 | |||||
heel bone mineral density | 3 | 4 | 6 | 94.5 | |||||
serum gamma-glutamyl transferase measurement | 2 | 2 | 3 | 93.1 | |||||
hematocrit | 2 | 2 | 3 | 93.1 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte measurement | 20 | 99.5 | |||||
reticulocyte count | 28 | 99.3 | |||||
heel bone mineral density | 6 | 94.5 | |||||
serum gamma-glutamyl transferase measurement | 3 | 93.1 | |||||
hematocrit | 3 | 93.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | proteinase 3 | 749895 | ||||||
Mouse | MGI:893580 | 19152 | ||||||
Rat | RGD:1304898 | 314615 | ||||||
Horse | proteinase 3 [Source:HGNC Symbol;Acc:HGNC:9495] | |||||||
Cow | proteinase 3 | VGNC:33427 | 100298591 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | proteinase 3 | |||||
Mouse | ||||||
Rat | ||||||
Horse | proteinase 3 [Source:HGNC Symbol;Acc:HGNC:9495] | |||||
Cow | proteinase 3 | |||||
Publication Statistics
PubMed Score 4704.34
PubMed score by year
PubTator Score 2361.27
PubTator score by year
Related Publications
Text Mined References (143)
GeneRif Annotations (102)
Items per page:
0 of 0
PMID | Year | Title |
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