Tchem PRTN3 Myeloblastin

Protein Summary

Description

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).

Uniprot Accession IDs

• P24158
• P15637
• P18078
• Q4VB08
• Q4VB09
• Q6LBM7
• Q6LBN2
• Q9UD25
• Q9UQD8

Gene Name

• PRTN3

Ensembl ID

• ENST00000234347
• ENSP00000234347
• ENSG00000196415
• ENST00000612112
• ENSP00000478977
• ENSG00000277804

Symbol

• MBN
• MBN
• MBT
• NP4
• P29
• PR3
• ACPA
• AGP7
• NP-4
• PR-3
• CANCA
• C-ANCA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.81
gene perturbation	0.81
cellular component	0.8
cell type or tissue	0.76
disease	0.65

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Myeloblastin

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Myeloblastin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4704.34   (req: < 5)

Gene RIFs: 102   (req: <= 3)

Antibodies: 478   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4704.34   (req: >= 5)

Gene RIFs: 102   (req: > 3)

Antibodies: 478   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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1 – 1 of 1

sivelestat

PRTN3Tchem Enzyme

pKi : 6.7

Active Ligands (19)

Explore Active Ligands

1 – 10 of 19

compound 4g [PMID: 22595175]

PRTN3Tchem Enzyme

pIC50 : 5.85

CHEMBL4557877

PRTN3Tchem Enzyme

pKi : 8.15

CHEMBL4560512

PRTN3Tchem Enzyme

pKi : 8.21

CHEMBL4455694

PRTN3Tchem Enzyme

pKi : 7.77

CHEMBL3398148

PRTN3Tchem Enzyme

pIC50 : 7.3

4-(N-(2-Acetylphenyl)sulfamoyl)phenyl pivalate

PRTN3Tchem Enzyme

pIC50 : 6.96

4-(N-(2-(2-Hydroxyethylcarbamoyl)phenyl)sulfamoyl)phenyl pivalate

PRTN3Tchem Enzyme

pIC50 : 6.89

US9073833, 5

PRTN3Tchem Enzyme

pIC50 : 6.77

2-hydroxyethyl 2-(4-(pivaloyloxy)phenylsulfonamido)benzoate

PRTN3Tchem Enzyme

pIC50 : 6.54

4-(N-(2-Butyrylphenyl)sulfamoyl)phenyl pivalate

PRTN3Tchem Enzyme

pIC50 : 6.44

Protein-Protein Interactions (203)

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1 – 10 of 203

• See Interactions on String-DB

XIAP

Tchem

Family:  Enzyme

Novelty:  0.00062268

p_int:  0.999956852

p_ni:  0.000043148

Data Source:  BioPlex

FBXO21

Tbio

Novelty:  0.2186203

p_int:  0.999767895

p_ni:  0.000232105

Data Source:  BioPlex

GOLIM4

Tbio

Novelty:  0.01923513

p_int:  0.999747494

p_ni:  0.000252505

p_wrong:  1e-9

Data Source:  BioPlex

SERPINB1

Tbio

Family:  Enzyme

Novelty:  0.00267786

p_int:  0.981843281

p_ni:  0.017744273

p_wrong:  0.000412446

Score:  0.755

Data Source:  BioPlex,STRINGDB

RAB3GAP1

Tbio

Family:  Enzyme

Novelty:  0.0286836

p_int:  0.978256955

p_ni:  0.021743012

p_wrong:  3.3e-8

Data Source:  BioPlex

SPCS1

Tbio

Family:  Enzyme

Novelty:  0.0731223

p_int:  0.976080227

p_ni:  0.005873529

p_wrong:  0.018046244

Data Source:  BioPlex

BIRC2

Tchem

Novelty:  0.00199701

p_int:  0.941731489

p_ni:  0.058268472

p_wrong:  3.8e-8

Data Source:  BioPlex

QRICH1

Tdark

Novelty:  0.27714699

p_int:  0.88343682

p_ni:  0.114446273

p_wrong:  0.002116907

Data Source:  BioPlex

SPCS2

Tdark

Family:  Enzyme

Novelty:  0.21358992

p_int:  0.859166522

p_ni:  0.140833478

Data Source:  BioPlex

DHPS

Tchem

Family:  Enzyme

Novelty:  0.00776893

p_int:  0.834817607

p_ni:  0.165181977

p_wrong:  4.16e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (11)

Reactome (10)

PathwayCommons (1)

Antimicrobial peptides (R-HSA-6803157)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antimicrobial peptides	89 targets	R-HSA-6803157
Reactome	Common Pathway of Fibrin Clot Formation	22 targets	R-HSA-140875
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Formation of Fibrin Clot (Clotting Cascade)	39 targets	R-HSA-140877
Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Antimicrobial peptides	89 targets	R-HSA-6803157
Common Pathway of Fibrin Clot Formation	22 targets	R-HSA-140875
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Formation of Fibrin Clot (Clotting Cascade)	39 targets	R-HSA-140877
Hemostasis	666 targets	R-HSA-109582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (25)

Functions (4)

Components (7)

Processes (14)

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1 – 4 of 4

GO Term	Evidence	Assigned by
serine-type endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
signaling receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
serine-type peptidase activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (21)

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1 – 5 of 21

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	3	13	20		99.5
reticulocyte count	EFO_0007986	7	10	28		99.3
heel bone mineral density	EFO_0009270	3	4	6		94.5
serum gamma-glutamyl transferase measurement	EFO_0004532	2	2	3		93.1
hematocrit	EFO_0004348	2	2	3		93.1

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1 – 5 of 21

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	20		99.5
reticulocyte count	EFO_0007986	28		99.3
heel bone mineral density	EFO_0009270	6		94.5
serum gamma-glutamyl transferase measurement	EFO_0004532	3		93.1
hematocrit	EFO_0004348	3		93.1

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell membrane
Collagen degradation
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Membrane
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
anti-neutrophil antibody associated vasculitis
aspartate aminotransferase measurement
basophil count
basophil percentage of granulocytes
basophil percentage of leukocytes
blood urea nitrogen measurement
C-reactive protein measurement
cup-to-disc ratio measurement
HbA1c measurement
heel bone mineral density

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	proteinase 3		749895
Mouse	proteinase 3	MGI:893580	19152
Rat	proteinase 3	RGD:1304898	314615
Horse	proteinase 3 [Source:HGNC Symbol;Acc:HGNC:9495]
Cow	proteinase 3	VGNC:33427	100298591

Species	Name	OMA	EggNOG	Inparanoid
Chimp	proteinase 3
Mouse	proteinase 3
Rat	proteinase 3
Horse	proteinase 3 [Source:HGNC Symbol;Acc:HGNC:9495]
Cow	proteinase 3

Publication Statistics

PubMed Score 4704.34

PubMed score by year

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PubTator Score 2361.27

PubTator score by year

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Related Publications

Text Mined References (143)

GeneRif Annotations (102)

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PMID	Year	Title