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Tchem
PRTN3
Myeloblastin

Protein Summary
Description
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234347
  • ENSP00000234347
  • ENSG00000196415
  • ENST00000612112
  • ENSP00000478977
  • ENSG00000277804

Symbol
  • MBN
  • MBN
  • MBT
  • NP4
  • P29
  • PR3
  • ACPA
  • AGP7
  • NP-4
  • PR-3
  • CANCA
  • C-ANCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.81
gene perturbation
0.81
cellular component
0.8
cell type or tissue
0.76
disease
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5828.42   (req: < 5)
Gene RIFs: 102   (req: <= 3)
Antibodies: 478   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5828.42   (req: >= 5)
Gene RIFs: 102   (req: > 3)
Antibodies: 478   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1