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Tbio
PRTG
Protogenin

Protein Summary
Description
May play a role in anteroposterior axis elongation. This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389286
  • ENSP00000373937
  • ENSG00000166450

Symbol
  • IGDCC5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.75
protein domain
0.73
transcription factor perturbation
0.68
virus perturbation
0.64
PubMedID
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.92   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.92   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (18)
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.999999068
p_ni:  2.91e-7
p_wrong:  6.41e-7
Score:  0.535
Data Source:  BioPlex,STRINGDB
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.999960729
p_ni:  0.000039127
p_wrong:  1.45e-7
Score:  0.571
Data Source:  BioPlex,STRINGDB
ZNF804A
Tbio
Novelty:  0.00751648
Score:  0.596
Data Source:  STRINGDB
TFCP2L1
Tbio
Family:  TF
Novelty:  0.04097991
Score:  0.574
Data Source:  STRINGDB
EXOC6B
Tbio
Novelty:  0.11301293
Score:  0.545
Data Source:  STRINGDB
PLEKHN1
Tbio
Novelty:  0.33160373
Score:  0.498
Data Source:  STRINGDB
KIF26B
Tbio
Novelty:  0.08162244
Score:  0.49
Data Source:  STRINGDB
PLEKHG4B
Tdark
Novelty:  1.0354449
Score:  0.479
Data Source:  STRINGDB
DAZAP2
Tbio
Novelty:  0.02387823
Score:  0.473
Data Source:  STRINGDB
DRAXIN
Tbio
Novelty:  0.05464381
Score:  0.47
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Neural Crest Differentiation
WikiPathways
Neural Crest Differentiation
WikiPathways
Neural Crest Differentiation
WikiPathways
Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs)
WikiPathways
Notch Signaling Pathway
Name
Explore in Pharos
Explore in Source
Neural Crest Differentiation
Neural Crest Differentiation
Neural Crest Differentiation
Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs)
Notch Signaling Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
50.6
1
1
0
1.4
35
risk-taking behaviour
1
1
1
17.8
1
1
0
1.2
11.9
intraocular pressure measurement
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
50.6
0
1.4
35
risk-taking behaviour
1
17.8
0
1.2
11.9
intraocular pressure measurement
1
8.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protogenin
VGNC:14727
453459
Macaque
protogenin
698623
Mouse
MGI:2444710
235472
Rat
RGD:1307157
315806
Dog
protogenin
VGNC:45076
487569
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protogenin
Macaque
protogenin
Mouse
Rat
Dog
protogenin
Publication Statistics
PubMed Score 20.92
PubMed score by year
PubTator Score 9.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title