Protein Summary
May play a role in anteroposterior axis elongation. This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). [provided by RefSeq, Nov 2014]
- ENST00000389286
- ENSP00000373937
- ENSG00000166450
- IGDCC5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.75 | ||
protein domain | 0.73 | ||
transcription factor perturbation | 0.68 | ||
virus perturbation | 0.64 | ||
PubMedID | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.92 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 64 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.92 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 64 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (18)
TMEM30B
Novelty: 0.26735006
p_int: 0.999999068
p_ni: 2.91e-7
p_wrong: 6.41e-7
Score: 0.535
Data Source: BioPlex,STRINGDB
FCGRT
Novelty: 0.00105713
p_int: 0.999960729
p_ni: 0.000039127
p_wrong: 1.45e-7
Score: 0.571
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (14)
WikiPathways (14)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Neural Crest Differentiation | ||||
WikiPathways | Neural Crest Differentiation | ||||
WikiPathways | Neural Crest Differentiation | ||||
WikiPathways | Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) | ||||
WikiPathways | Notch Signaling Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Neural Crest Differentiation | ||||
Neural Crest Differentiation | ||||
Neural Crest Differentiation | ||||
Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) | ||||
Notch Signaling Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (1)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 1 | 1 | 50.6 | |||||
1 | 1 | 0 | 1.4 | 35 | |||||
risk-taking behaviour | 1 | 1 | 1 | 17.8 | |||||
1 | 1 | 0 | 1.2 | 11.9 | |||||
intraocular pressure measurement | 1 | 1 | 1 | 8.7 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 50.6 | |||||
0 | 1.4 | 35 | |||||
risk-taking behaviour | 1 | 17.8 | |||||
0 | 1.2 | 11.9 | |||||
intraocular pressure measurement | 1 | 8.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | protogenin | VGNC:14727 | 453459 | |||||
Macaque | protogenin | 698623 | ||||||
Mouse | MGI:2444710 | 235472 | ||||||
Rat | RGD:1307157 | 315806 | ||||||
Dog | protogenin | VGNC:45076 | 487569 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | protogenin | |||||
Macaque | protogenin | |||||
Mouse | ||||||
Rat | ||||||
Dog | protogenin | |||||
Publication Statistics
PubMed Score 20.92
PubMed score by year
PubTator Score 9.03
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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