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Tbio
PRTFDC1
Phosphoribosyltransferase domain-containing protein 1

Protein Summary
Description
Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320152
  • ENSP00000318602
  • ENSG00000099256
  • ENST00000376376
  • ENSP00000365556
  • ENST00000376378
  • ENSP00000365558

Symbol
  • HHGP
  • HHGP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.83
histone modification site profile
0.72
molecular function
0.7
tissue sample
0.69
cell type or tissue
0.67


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.91   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.91   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
HPRT1
Tchem
Family:  Enzyme
Novelty:  0.00032232
p_int:  0.999999949
p_ni:  2e-9
p_wrong:  5e-8
Score:  0.804
Data Source:  BioPlex,STRINGDB
MED7
Tbio
Family:  Enzyme
Novelty:  0.04773947
p_int:  0.994893181
p_ni:  0.001271228
p_wrong:  0.003835592
Data Source:  BioPlex
NABP2
Tbio
Novelty:  0.09046897
p_int:  0.994267989
p_ni:  0.000385077
p_wrong:  0.005346934
Data Source:  BioPlex
SPRED2
Tbio
Novelty:  0.04447225
p_int:  0.992377425
p_ni:  0.000607319
p_wrong:  0.007015256
Score:  0.225
Data Source:  BioPlex,STRINGDB
SPINK2
Tdark
Family:  Enzyme
Novelty:  0.06832697
p_int:  0.991941354
p_ni:  0.001610089
p_wrong:  0.006448557
Data Source:  BioPlex
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.989396918
p_ni:  0.002075391
p_wrong:  0.008527691
Data Source:  BioPlex
MYEOV
Tbio
Novelty:  0.04142875
p_int:  0.985019062
p_ni:  0.004077268
p_wrong:  0.01090367
Score:  0.455
Data Source:  BioPlex,STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
p_int:  0.985019062
p_ni:  0.004077268
p_wrong:  0.01090367
Score:  0.201
Data Source:  BioPlex,STRINGDB
HSD17B6
Tbio
Family:  Enzyme
Novelty:  0.01428594
p_int:  0.985019062
p_ni:  0.004077268
p_wrong:  0.01090367
Score:  0.187
Data Source:  BioPlex,STRINGDB
FCGR2A
Tbio
Novelty:  0.00078918
p_int:  0.985019062
p_ni:  0.004077268
p_wrong:  0.01090367
Score:  0.163
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Adenine and hypoxanthine salvage pathway
PathwayCommons: panther
Xanthine and guanine salvage pathway
Name
Explore in Pharos
Explore in Source
Adenine and hypoxanthine salvage pathway
Xanthine and guanine salvage pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
3
9
95.3
neutrophil count
4
4
4
90.1
monocyte count
3
3
3
89.4
leukocyte count
3
3
3
89.2
lymphocyte count
4
3
4
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
9
95.3
neutrophil count
4
90.1
monocyte count
3
89.4
leukocyte count
3
89.2
lymphocyte count
4
88
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoribosyl transferase domain containing 1
VGNC:12437
450356
Macaque
phosphoribosyl transferase domain containing 1
712819
Rat
RGD:1310177
291355
Dog
phosphoribosyl transferase domain containing 1
VGNC:45075
487103
Horse
phosphoribosyl transferase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23333]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoribosyl transferase domain containing 1
Macaque
phosphoribosyl transferase domain containing 1
Rat
Dog
phosphoribosyl transferase domain containing 1
Horse
phosphoribosyl transferase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23333]
Publication Statistics
PubMed Score 7.91
PubMed score by year
PubTator Score 4.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title