Protein Summary
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]
- ENST00000317508
- ENSP00000319730
- ENSG00000052344
- ENST00000568261
- ENSP00000457750
- CAP1
- PROSTASIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.91 | ||
PubMedID | 0.9 | ||
cellular component | 0.72 | ||
transcription factor perturbation | 0.61 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 136.25 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 273 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 136.25 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 273 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 15
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (15)
Protein-Protein Interactions (37)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (7)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
IGF-1 measurement | 1 | 3 | 3 | 82.8 | |||||
response to anticoagulant | 1 | 1 | 0 | 20.4 | 81 | ||||
triglyceride measurement | 3 | 3 | 3 | 72.3 | |||||
body mass index | 5 | 2 | 6 | 71.6 | |||||
waist circumference | 2 | 2 | 2 | 67.4 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
IGF-1 measurement | 3 | 82.8 | |||||
response to anticoagulant | 0 | 20.4 | 81 | ||||
triglyceride measurement | 3 | 72.3 | |||||
body mass index | 6 | 71.6 | |||||
waist circumference | 2 | 67.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serine protease 8 | VGNC:5903 | 454065 | |||||
Macaque | protease, serine 8 | 713176 | ||||||
Mouse | MGI:1923810 | 76560 | ||||||
Rat | RGD:619973 | 192107 | ||||||
Dog | serine protease 8 | VGNC:45074 | 102157328 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serine protease 8 | |||||
Macaque | protease, serine 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | serine protease 8 | |||||
Publication Statistics
PubMed Score 136.25
PubMed score by year
PubTator Score 93.19
PubTator score by year
Related Publications
Text Mined References (62)
GeneRif Annotations (45)
Items per page:
0 of 0
PMID | Year | Title |
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