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Tdark
PRSS58
Serine protease 58

Protein Summary
Description
This gene encodes a member of the trypsin family of serine proteases. This gene and several related trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. This gene was previously described as a trypsinogen-like pseudogene, but it is now thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000547058
  • ENSP00000447588
  • ENSG00000258223
  • ENST00000552471
  • ENSP00000446916
  • ENST00000621886
  • ENSP00000478535
  • ENSG00000276785
  • ENST00000622880
  • ENSP00000479165

Symbol
  • TRY1
  • TRYX3
  • TRY1
  • PRSS1
  • TRYX3
  • UNQ2540
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
gene perturbation
0.47
tissue
0.47
cell line
0.42
tissue sample
0.36


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.17   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.17   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
SPINK1
Tbio
Family:  Enzyme
Novelty:  0.00074416
Score:  0.86
Data Source:  STRINGDB
HTRA4
Tbio
Family:  Enzyme
Novelty:  0.09298487
Score:  0.724
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.679
Data Source:  STRINGDB
PALB2
Tbio
Novelty:  0.00320056
Score:  0.669
Data Source:  STRINGDB
STK11
Tchem
Family:  Kinase
Novelty:  0.00073247
Score:  0.643
Data Source:  STRINGDB
MGAM
Tclin
Family:  Enzyme
Novelty:  0.00045865
Score:  0.64
Data Source:  STRINGDB
BRCA2
Tbio
Novelty:  0.0002217
Score:  0.634
Data Source:  STRINGDB
DBH
Tchem
Family:  Enzyme
Novelty:  0.00074741
Score:  0.626
Data Source:  STRINGDB
MOXD1
Tbio
Family:  Enzyme
Novelty:  0.00571213
Score:  0.626
Data Source:  STRINGDB
HOXA6
Tbio
Family:  TF
Novelty:  0.04558872
Score:  0.621
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
2
1
1
0
1.3
2
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
2
0
1.3
2
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine protease 58
VGNC:14079
742071
Macaque
protease, serine 58
696251
Mouse
MGI:3608323
232717
Rat
RGD:1303054
408204
Dog
serine protease 58-like
475522
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine protease 58
Macaque
protease, serine 58
Mouse
Rat
Dog
serine protease 58-like
Publication Statistics
PubMed Score 74.17
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title