Protein Summary
This gene encodes a member of the trypsin family of serine proteases. This gene and several related trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. This gene was previously described as a trypsinogen-like pseudogene, but it is now thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]
- ENST00000547058
- ENSP00000447588
- ENSG00000258223
- ENST00000552471
- ENSP00000446916
- ENST00000621886
- ENSP00000478535
- ENSG00000276785
- ENST00000622880
- ENSP00000479165
- TRY1
- TRYX3
- TRY1
- PRSS1
- TRYX3
- UNQ2540
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.58 | ||
gene perturbation | 0.47 | ||
tissue | 0.47 | ||
cell line | 0.42 | ||
tissue sample | 0.36 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 74.17 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 32 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 74.17 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 32 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (28)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (3)
Functions (1)
Components (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (2)
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1 – 2 of 2
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.3 | 2 | ||||||
1 | 1 | 0 | 1.3 | 2 | ||||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 2 | |||||
0 | 1.3 | 2 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serine protease 58 | VGNC:14079 | 742071 | |||||
Macaque | protease, serine 58 | 696251 | ||||||
Mouse | MGI:3608323 | 232717 | ||||||
Rat | RGD:1303054 | 408204 | ||||||
Dog | serine protease 58-like | 475522 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serine protease 58 | |||||
Macaque | protease, serine 58 | |||||
Mouse | ||||||
Rat | ||||||
Dog | serine protease 58-like | |||||
Publication Statistics
PubMed Score 74.17
PubMed score by year
Related Publications
Text Mined References (7)
Items per page:
0 of 0
PMID | Year | Title |
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