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Tbio
PRSS57
Serine protease 57

Protein Summary
Description
Serine protease that cleaves preferentially after Arg residues (PubMed:22474388, PubMed:23904161, PubMed:25156428). Can also cleave after citrulline (deimidated arginine) and methylarginine residues (PubMed:25156428). This gene encodes an arginine-specific serine protease and member of the peptidase S1 family of proteins. The encoded protein may undergo proteolytic activation before storage in azurophil granules, in neutrophil cells of the immune system. Following neutrophil activation, the protease is released into the pericellular environment, where it may play a role in defense against microbial pathogens. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000613411
  • ENSP00000482358
  • ENSG00000185198

Symbol
  • PRSSL1
  • NSP4
  • PRSSL1
  • UNQ782
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.6
protein domain
0.58
tissue
0.44
transcription factor
0.39
biological term
0.33


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.7   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.7   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
SH2D3A
Tbio
Novelty:  0.00185943
Score:  0.955
Data Source:  STRINGDB
SH2D3C
Tbio
Novelty:  0.00356605
Score:  0.954
Data Source:  STRINGDB
SPECC1
Tbio
Novelty:  0.00830299
Score:  0.922
Data Source:  STRINGDB
BAG6
Tbio
Novelty:  0.0035578
Score:  0.788
Data Source:  STRINGDB
C6orf48
Tdark
Novelty:  0.00615017
Score:  0.787
Data Source:  STRINGDB
MRPL58
Tbio
Family:  Enzyme
Novelty:  0.00178011
Score:  0.763
Data Source:  STRINGDB
KIR2DL4
Tbio
Novelty:  0.00163053
Score:  0.709
Data Source:  STRINGDB
MPO
Tchem
Family:  Enzyme
Novelty:  0.00020698
Score:  0.631
Data Source:  STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.629
Data Source:  STRINGDB
CLIC1
Tbio
Family:  IC
Novelty:  0.00622691
Score:  0.588
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
58.4
worry measurement
2
2
1
5.8
47.5
sex hormone-binding globulin measurement
3
2
3
41.9
cognitive function measurement
2
1
2
31.4
mathematical ability
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
58.4
worry measurement
1
5.8
47.5
sex hormone-binding globulin measurement
3
41.9
cognitive function measurement
2
31.4
mathematical ability
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine protease 57
VGNC:3609
740772
Macaque
protease, serine 57
721106
Mouse
MGI:1920356
73106
Rat
RGD:1303330
408241
Dog
serine protease 57
VGNC:54343
485099
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine protease 57
Macaque
protease, serine 57
Mouse
Rat
Dog
serine protease 57
Publication Statistics
PubMed Score 412.70
PubMed score by year
PubTator Score 289.56
PubTator score by year
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Related Publications
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PMID
Year
Title