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Tdark
PRSS37
Probable inactive serine protease 37

Protein Summary
Description
Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system (PubMed:27649891).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350549
  • ENSP00000297767
  • ENSG00000165076
  • ENST00000438520
  • ENSP00000414461

Symbol
  • TRYX2
  • TRYX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
cell line
0.49
gene perturbation
0.43
protein domain
0.41
tissue
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.97   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.97   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
LRP5
Tbio
Novelty:  0.00089807
p_int:  0.998650834
p_ni:  0.001349166
Data Source:  BioPlex
CD109
Tbio
Novelty:  0.01280272
p_int:  0.956689035
p_ni:  0.043310959
p_wrong:  6e-9
Data Source:  BioPlex
FUT11
Tbio
Family:  Enzyme
Novelty:  0.16098097
p_int:  0.948415803
p_ni:  0.051581097
p_wrong:  0.0000031
Data Source:  BioPlex
MANBA
Tchem
Family:  Enzyme
Novelty:  0.00961026
p_int:  0.937853173
p_ni:  0.062146827
Score:  0.169
Data Source:  BioPlex,STRINGDB
LRP6
Tbio
Novelty:  0.00305615
p_int:  0.915092041
p_ni:  0.084907959
Data Source:  BioPlex
AKAP1
Tbio
Family:  Epigenetic
Novelty:  0.00437217
p_int:  0.901280943
p_ni:  0.098719056
Score:  0.189
Data Source:  BioPlex,STRINGDB
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
p_int:  0.890527948
p_ni:  0.108439126
p_wrong:  0.001032926
Data Source:  BioPlex
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.839771221
p_ni:  0.160228779
Data Source:  BioPlex
PCDH20
Tbio
Novelty:  0.07862843
p_int:  0.836870899
p_ni:  0.163129101
Data Source:  BioPlex
UBR5
Tbio
Family:  Enzyme
Novelty:  0.00608732
p_int:  0.82796005
p_ni:  0.172039949
Score:  0.169
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
15.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
15.5
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914940
67690
Rat
RGD:1311823
362346
Dog
serine protease 37
VGNC:45068
482761
Horse
serine protease 37
VGNC:21918
100064541
Cow
serine protease 37
VGNC:33420
540062
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
serine protease 37
Horse
serine protease 37
Cow
serine protease 37
Publication Statistics
PubMed Score 3.97
PubMed score by year
PubTator Score 0.77
PubTator score by year
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Related Publications
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PMID
Year
Title