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Tbio
PRSS35
Inactive serine protease 35

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369700
  • ENSP00000358714
  • ENSG00000146250

Symbol
  • C6orf158
  • C6orf158
  • dJ223E3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
histone modification site profile
0.68
tissue
0.63
cell type or tissue
0.61
microRNA
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.61   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.61   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
CFAP206
Tdark
Novelty:  1.22847252
Score:  0.783
Data Source:  STRINGDB
UBE3D
Tbio
Family:  Enzyme
Novelty:  0.44919491
Score:  0.781
Data Source:  STRINGDB
PUDP
Tbio
Family:  Enzyme
Novelty:  0.11180277
Score:  0.738
Data Source:  STRINGDB
CYB5R4
Tbio
Family:  Enzyme
Novelty:  0.06424571
Score:  0.727
Data Source:  STRINGDB
DOP1A
Tdark
Novelty:  0.040097
Score:  0.724
Data Source:  STRINGDB
SNAP91
Tbio
Novelty:  0.0083886
Score:  0.719
Data Source:  STRINGDB
SMTNL2
Tdark
Novelty:  0.33805653
Score:  0.695
Data Source:  STRINGDB
PNPLA4
Tbio
Family:  Enzyme
Novelty:  0.07471752
Score:  0.688
Data Source:  STRINGDB
PGM3
Tbio
Family:  Enzyme
Novelty:  0.00515842
Score:  0.634
Data Source:  STRINGDB
HTR1E
Tchem
Family:  GPCR
Novelty:  0.02160816
Score:  0.632
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical thickness
1
1
0
9.4
63.7
schizophrenia
3
2
0
1.1
58
refractive error
1
1
1
50
ganglion cell inner plexiform layer thickness measurement
1
1
1
49.4
snoring measurement
1
1
1
37.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical thickness
0
9.4
63.7
schizophrenia
0
1.1
58
refractive error
1
50
ganglion cell inner plexiform layer thickness measurement
1
49.4
snoring measurement
1
37.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine protease 35
VGNC:3674
472062
Macaque
protease, serine 35
695095
Mouse
MGI:2444800
244954
Rat
RGD:1311282
315866
Dog
serine protease 35
VGNC:45066
481902
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine protease 35
Macaque
protease, serine 35
Mouse
Rat
Dog
serine protease 35
Publication Statistics
PubMed Score 7.61
PubMed score by year
PubTator Score 2.15
PubTator score by year
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Related Publications
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PMID
Year
Title