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Tchem
PRSS3
Trypsin-3

Protein Summary
Description
Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342836
  • ENSP00000340889
  • ENSG00000010438
  • ENST00000361005
  • ENSP00000354280
  • ENST00000379405
  • ENSP00000368715
  • ENST00000429677
  • ENSP00000401828

Symbol
  • PRSS4
  • TRY3
  • TRY4
  • T9
  • MTG
  • TRY3
  • TRY4
  • PRSS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.66
pathway
0.58
protein domain
0.58
drug
0.54
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 385.35   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 385.35   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1