PRSS23
Serine protease 23
Protein Summary
This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
- ENST00000280258
- ENSP00000280258
- ENSG00000150687
- ZSIG13
- SIG13
- SPUVE
- ZSIG13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
PubMedID | 0.99 | ||
small molecule perturbation | 0.73 | ||
kinase perturbation | 0.71 | ||
disease perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.6 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 68 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.6 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 68 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (123)
KLRG2
Novelty: 1.19446694
p_int: 0.999195735
p_ni: 0.000008784
p_wrong: 0.00079548
Data Source: BioPlex
ACTB
Novelty: 0.00006048
p_int: 0.950714248
p_ni: 0.049285752
Score: 0.278
Data Source: BioPlex,STRINGDB
COL5A1
Novelty: 0.00506815
p_int: 0.943247269
p_ni: 0.000159095
p_wrong: 0.056593635
Score: 0.322
Data Source: BioPlex,STRINGDB
SCGB2A2
Novelty: 0.01594053
p_int: 0.933426938
p_ni: 0.000074456
p_wrong: 0.066498606
Data Source: BioPlex
UBR1
Family: Enzyme
Novelty: 0.00998888
p_int: 0.759485774
p_ni: 0.240514226
Score: 0.183
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (1)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 2 | 4 | 93.7 | |||||
intraocular pressure measurement | 3 | 4 | 5 | 81.5 | |||||
blood urea nitrogen measurement | 1 | 1 | 1 | 56.6 | |||||
cup-to-disc ratio measurement | 2 | 2 | 2 | 54.3 | |||||
serum urea measurement | 1 | 1 | 1 | 36.9 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 4 | 93.7 | |||||
intraocular pressure measurement | 5 | 81.5 | |||||
blood urea nitrogen measurement | 1 | 56.6 | |||||
cup-to-disc ratio measurement | 2 | 54.3 | |||||
serum urea measurement | 1 | 36.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | protease, serine 23 | 704537 | ||||||
Mouse | MGI:1923703 | 76453 | ||||||
Rat | RGD:1359545 | 308807 | ||||||
Dog | serine protease 23 | VGNC:45065 | 485150 | |||||
Horse | serine protease 23 | VGNC:21914 | 100060937 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | protease, serine 23 | |||||
Mouse | ||||||
Rat | ||||||
Dog | serine protease 23 | |||||
Horse | serine protease 23 | |||||
Publication Statistics
PubMed Score 10.60
PubMed score by year
PubTator Score 3.00
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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