You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
PRSS22
Brain-specific serine protease 4

Protein Summary
Description
Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000161006
  • ENSP00000161006
  • ENSG00000005001
  • ENST00000642189
  • ENSP00000495133
  • ENSG00000282937
  • ENST00000645000
  • ENSP00000496223

Symbol
  • BSSP4
  • PRSS26
  • BSSP-4
  • SP001LA
  • hBSSP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
kinase perturbation
0.66
protein domain
0.58
cell type or tissue
0.56
disease perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.2   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.2   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
p_int:  0.998435309
p_ni:  0.001564691
Score:  0.297
Data Source:  BioPlex,STRINGDB
FAM183A
Tdark
Novelty:  1.89421433
Score:  0.649
Data Source:  STRINGDB
FAM183BP
Tdark
Novelty:  0.71794872
Score:  0.626
Data Source:  STRINGDB
MOB4
Tbio
Novelty:  0.03238981
Score:  0.593
Data Source:  STRINGDB
PRRG2
Tbio
Novelty:  0.16164794
Score:  0.514
Data Source:  STRINGDB
SYT17
Tbio
Novelty:  0.03921503
Score:  0.513
Data Source:  STRINGDB
CTXN3
Tbio
Novelty:  0.10303512
Score:  0.512
Data Source:  STRINGDB
PLEKHF1
Tbio
Novelty:  0.02694931
Score:  0.51
Data Source:  STRINGDB
ATP1A4
Tclin
Family:  Transporter
Novelty:  0.01011201
Score:  0.488
Data Source:  STRINGDB
NDFIP2
Tbio
Novelty:  0.13102829
Score:  0.485
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
93.4
eosinophil count
3
3
3
93.4
eosinophil percentage of leukocytes
2
2
2
87.5
eosinophil percentage of leukocytes
2
2
2
87.5
body height
1
1
1
65.5
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
93.4
eosinophil count
3
93.4
eosinophil percentage of leukocytes
2
87.5
eosinophil percentage of leukocytes
2
87.5
body height
1
65.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine protease 22
VGNC:5898
453846
Mouse
MGI:1918085
70835
Rat
RGD:1310880
302971
Dog
serine protease 22
VGNC:45064
490056
Horse
brain-specific serine protease 4
100068549
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine protease 22
Mouse
Rat
Dog
serine protease 22
Horse
brain-specific serine protease 4
Publication Statistics
PubMed Score 4.20
PubMed score by year
PubTator Score 4.70
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title