PRSS21
Testisin
Protein Summary
Could regulate proteolytic events associated with testicular germ cell maturation. This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
- ENST00000005995
- ENSP00000005995
- ENSG00000007038
- ENST00000450020
- ENSP00000407741
- ENST00000634351
- ENSP00000489315
- ENSG00000282838
- ENST00000634454
- ENSP00000489081
- ESP1
- TEST1
- ESP1
- ESP-1
- TEST1
- TESTISIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease | 0.99 | ||
gene perturbation | 0.7 | ||
protein domain | 0.58 | ||
tissue sample | 0.54 | ||
tissue | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 183.61 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 55 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 183.61 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 55 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0