Protein Summary
Could regulate proteolytic events associated with testicular germ cell maturation. This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
- ENST00000005995
- ENSP00000005995
- ENSG00000007038
- ENST00000450020
- ENSP00000407741
- ENST00000634351
- ENSP00000489315
- ENSG00000282838
- ENST00000634454
- ENSP00000489081
- ESP1
- TEST1
- ESP1
- ESP-1
- TEST1
- TESTISIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease | 0.99 | ||
gene perturbation | 0.7 | ||
protein domain | 0.58 | ||
tissue sample | 0.54 | ||
tissue | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 91.32 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 55 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 91.32 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 55 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (97)
BST1
Family: Enzyme
Novelty: 0.01329061
p_int: 0.999795291
p_ni: 0.000009062
p_wrong: 0.000195647
Score: 0.9
Data Source: BioPlex,STRINGDB
SMOC1
Novelty: 0.03819681
p_int: 0.994388337
p_ni: 0.005528486
p_wrong: 0.000083178
Data Source: BioPlex
ALG9
Family: Enzyme
Novelty: 0.02975572
p_int: 0.982474348
p_ni: 0.017523821
p_wrong: 0.000001831
Data Source: BioPlex
SPCS1
Family: Enzyme
Novelty: 0.0731223
p_int: 0.974176659
p_ni: 0.009137352
p_wrong: 0.01668599
Data Source: BioPlex
FKBP14
Family: Enzyme
Novelty: 0.02742616
p_int: 0.955359667
p_ni: 0.044639181
p_wrong: 0.000001152
Data Source: BioPlex
ROBO1
Novelty: 0.00494884
p_int: 0.917954163
p_ni: 0.001463669
p_wrong: 0.080582168
Data Source: BioPlex
ABHD17B
Family: Enzyme
Novelty: 0.64360453
p_int: 0.85323527
p_ni: 0.078096524
p_wrong: 0.068668206
Data Source: BioPlex
FSTL1
Novelty: 0.00557848
p_int: 0.835528861
p_ni: 0.154708532
p_wrong: 0.009762607
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational modification: synthesis of GPI-anchored proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational modification: synthesis of GPI-anchored proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (6)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 3 | 3 | 93.4 | ||||||
eosinophil count | 3 | 3 | 3 | 93.4 | ||||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 87.5 | ||||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 87.5 | ||||||
body height | 1 | 1 | 1 | 65.5 | ||||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 93.4 | |||||
eosinophil count | 3 | 93.4 | |||||
eosinophil percentage of leukocytes | 2 | 87.5 | |||||
eosinophil percentage of leukocytes | 2 | 87.5 | |||||
body height | 1 | 65.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serine protease 21 | VGNC:4832 | 453844 | |||||
Macaque | protease, serine 21 | 699296 | ||||||
Mouse | MGI:1916698 | 57256 | ||||||
Rat | RGD:727870 | 353251 | ||||||
Pig | testisin-like | 100737333 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serine protease 21 | |||||
Macaque | protease, serine 21 | |||||
Mouse | ||||||
Rat | ||||||
Pig | testisin-like | |||||
Publication Statistics
PubMed Score 91.32
PubMed score by year
PubTator Score 560.87
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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