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Tchem
PRSS12
Neurotrypsin

Protein Summary
Description
Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296498
  • ENSP00000296498
  • ENSG00000164099

Symbol
  • MRT1
  • BSSP3
  • BSSP-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.98
histone modification site profile
0.79
virus perturbation
0.79
cell type or tissue
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.88   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.88   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (34)
INS
Tbio
Novelty:  0.00000499
p_int:  0.921444542
p_ni:  0.000040009
p_wrong:  0.078515449
Data Source:  BioPlex
LY86
Tbio
Novelty:  0.00314575
p_int:  0.899447568
p_ni:  0.00060631
p_wrong:  0.099946122
Data Source:  BioPlex
MFAP5
Tbio
Novelty:  0.01839035
p_int:  0.877965184
p_ni:  0.00039733
p_wrong:  0.121637486
Data Source:  BioPlex
MSMB
Tbio
Novelty:  0.00241546
p_int:  0.846074501
p_ni:  0.0021184
p_wrong:  0.151807099
Data Source:  BioPlex
CC2D1A
Tbio
Novelty:  0.01970021
Score:  0.756
Data Source:  STRINGDB
CRBN
Tclin
Novelty:  0.00385433
Score:  0.752
Data Source:  STRINGDB
F3
Tchem
Novelty:  0.00006457
Score:  0.749
Data Source:  STRINGDB
AGRN
Tbio
Novelty:  0.00156441
Score:  0.745
Data Source:  STRINGDB
CA4
Tclin
Family:  Enzyme
Novelty:  0.0004916
Score:  0.632
Data Source:  STRINGDB
DPP3
Tbio
Family:  Enzyme
Novelty:  0.00763153
Score:  0.602
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood trauma measurement
1
1
1
2.5
neuroticism measurement
1
1
0
5.5
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood trauma measurement
1
2.5
neuroticism measurement
0
5.5
1.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine protease 12
VGNC:2965
471291
Macaque
protease, serine 12
704461
Mouse
MGI:1100881
19142
Rat
RGD:69238
85266
Dog
serine protease 12
VGNC:45062
100687821
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine protease 12
Macaque
protease, serine 12
Mouse
Rat
Dog
serine protease 12
Publication Statistics
PubMed Score 40.88
PubMed score by year
PubTator Score 22.51
PubTator score by year
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Related Publications
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PMID
Year
Title