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Tclin
PRSS1
Trypsin-1

Protein Summary
Description
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates. This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311737
  • ENSP00000308720
  • ENSG00000204983
  • ENST00000616256
  • ENSP00000479217
  • ENSG00000274247

Symbol
  • TRP1
  • TRY1
  • TRYP1
  • TRP1
  • TRY1
  • TRY4
  • TRYP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
gene perturbation
0.76
cell type or tissue
0.73
cell line
0.69
disease
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 692.87   (req: < 5)
Gene RIFs: 112   (req: <= 3)
Antibodies: 502   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 692.87   (req: >= 5)
Gene RIFs: 112   (req: > 3)
Antibodies: 502   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 889
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2