Tbio PRRG4 Transmembrane gamma-carboxyglutamic acid protein 4

Protein Summary

Description

May control axon guidance across the CNS (PubMed:28859078). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (PubMed:28859078).

Uniprot Accession IDs

• Q9BZD6

Gene Name

• PRRG4

Ensembl ID

• ENST00000257836
• ENSP00000257836
• ENSG00000135378

Symbol

• PRGP4
• TMG4
• TMG4
• PRGP4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
transcription factor perturbation	0.8
PubMedID	0.68
kinase perturbation	0.66
virus perturbation	0.64

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Transmembrane Gamma-carboxyglutamic Acid Protein 4

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Transmembrane Gamma-carboxyglutamic Acid Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.5   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 38   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.5   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0