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Tbio
PRRC2A
Protein PRRC2A

Protein Summary
Description
May play a role in the regulation of pre-mRNA splicing. A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376007
  • ENSP00000365175
  • ENSG00000204469
  • ENST00000376033
  • ENSP00000365201
  • ENST00000383455
  • ENSP00000372947
  • ENSG00000206427
  • ENST00000383464
  • ENSP00000372956
  • ENST00000414956
  • ENSP00000404619
  • ENSG00000226618
  • ENST00000416335
  • ENSP00000415182
  • ENSG00000231370
  • ENST00000422962
  • ENSP00000415363
  • ENSG00000231825
  • ENST00000428775
  • ENSP00000387910
  • ENSG00000225164
  • ENST00000430737
  • ENSP00000413977
  • ENST00000432252
  • ENSP00000408226
  • ENSG00000225748
  • ENST00000435971
  • ENSP00000409444
  • ENST00000439762
  • ENSP00000400540
  • ENST00000454306
  • ENSP00000387477
  • ENST00000458561
  • ENSP00000396812

Symbol
  • BAT2
  • G2
  • G2
  • BAT2
  • D6S51
  • D6S51E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
0.88
hub protein
0.85
disease
0.84
phenotype
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.85   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 10   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.85   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999999507
p_ni:  4.89e-7
p_wrong:  3e-9
Data Source:  BioPlex
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999947421
p_ni:  0.000052573
p_wrong:  6e-9
Data Source:  BioPlex
SFPQ
Tbio
Novelty:  0.01207637
p_int:  0.99983284
p_ni:  0.000167151
p_wrong:  9e-9
Score:  0.161
Data Source:  BioPlex,STRINGDB
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.999640317
p_ni:  0.000359682
p_wrong:  1e-9
Data Source:  BioPlex
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.999054005
p_ni:  0.000945995
p_wrong:  1e-9
Data Source:  BioPlex
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.997965056
p_ni:  0.002034939
p_wrong:  5e-9
Data Source:  BioPlex
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.992781565
p_ni:  0.0072166
p_wrong:  0.000001835
Score:  0.552
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.988978253
p_ni:  0.011021746
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.988480534
p_ni:  0.011519465
p_wrong:  1e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
CAPN13
Tdark
Novelty:  0.27206398
p_int:  0.980841005
p_ni:  0.019158995
Score:  0.187
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (602)
Items per page:
1 – 5 of 602
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
3
0
3
96.3
1
3
0
3
96.3
1
3
0
3
96.3
1
3
0
3
96.3
1
3
0
3
96.3
Items per page:
1 – 5 of 602
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3
96.3
0
3
96.3
0
3
96.3
0
3
96.3
0
3
96.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
proline rich coiled-coil 2A
715715
Mouse
MGI:1915467
53761
Rat
RGD:1303025
294250
Dog
proline rich coiled-coil 2A
VGNC:45052
481713
Horse
proline rich coiled-coil 2A
VGNC:21906
100050226
Species
Name
OMA
EggNOG
Inparanoid
Macaque
proline rich coiled-coil 2A
Mouse
Rat
Dog
proline rich coiled-coil 2A
Horse
proline rich coiled-coil 2A
Publication Statistics
PubMed Score 74.85
PubMed score by year
PubTator Score 104.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title