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Tbio
PRR7
Proline-rich protein 7

Protein Summary
Description
Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323249
  • ENSP00000327168
  • ENSG00000131188
  • ENST00000502922
  • ENSP00000420872
  • ENST00000510492
  • ENSP00000421039
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.87
transcription factor binding site profile
0.76
small molecule perturbation
0.73
histone modification site profile
0.66
tissue sample
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.73   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.73   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
PRR9
Tdark
Novelty:  0.09345601
Score:  0.836
Data Source:  STRINGDB
PRR5
Tbio
Novelty:  0.03269368
Score:  0.709
Data Source:  STRINGDB
FAM193B
Tdark
Novelty:  1.69956634
Score:  0.698
Data Source:  STRINGDB
TMED9
Tbio
Novelty:  0.24024246
Score:  0.647
Data Source:  STRINGDB
ASDURF
Tdark
Novelty:  0.54006324
Score:  0.642
Data Source:  STRINGDB
ASNSD1
Tdark
Family:  Enzyme
Novelty:  0.54006324
Score:  0.642
Data Source:  STRINGDB
NOP16
Tdark
Novelty:  0.27480251
Score:  0.626
Data Source:  STRINGDB
B4GALT7
Tbio
Family:  Enzyme
Novelty:  0.02175499
Score:  0.608
Data Source:  STRINGDB
HIBCH
Tbio
Family:  Enzyme
Novelty:  0.02964018
Score:  0.603
Data Source:  STRINGDB
DHRS7B
Tdark
Family:  Enzyme
Novelty:  0.59548345
Score:  0.594
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (58)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
12
9
14
15.2
99.1
partial thromboplastin time
2
2
2
98.8
creatinine measurement
7
7
8
8.5
97.8
4
4
0
1.2
97.2
blood protein measurement
41
5
41
95.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
14
15.2
99.1
partial thromboplastin time
2
98.8
creatinine measurement
8
8.5
97.8
0
1.2
97.2
blood protein measurement
41
95.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proline rich 7, synaptic
VGNC:14456
462306
Mouse
MGI:3487246
432763
Rat
RGD:1561898
498704
Dog
proline rich 7, synaptic
VGNC:45049
611253
Horse
proline rich 7, synaptic [Source:HGNC Symbol;Acc:HGNC:28130]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proline rich 7, synaptic
Mouse
Rat
Dog
proline rich 7, synaptic
Horse
proline rich 7, synaptic [Source:HGNC Symbol;Acc:HGNC:28130]
Publication Statistics
PubMed Score 15.73
PubMed score by year
PubTator Score 2.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title