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Tbio
PRR5
Proline-rich protein 5

Protein Summary
Description
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. This gene encodes a protein with a proline-rich domain. This gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000006251
  • ENSP00000006251
  • ENSG00000186654
  • ENST00000336985
  • ENSP00000337464
  • ENST00000403581
  • ENSP00000384848
  • ENST00000611394
  • ENSP00000480357
  • ENST00000617066
  • ENSP00000479623
  • ENST00000624862
  • ENSP00000485597

Symbol
  • PROTOR1
  • PP610
  • PROTOR1
  • PROTOR-1
  • FLJ20185k
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.82
tissue sample
0.69
disease perturbation
0.62
histone modification site profile
0.62
transcription factor binding site profile
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.42   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.42   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0