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Tbio
PRR5
Proline-rich protein 5

Protein Summary
Description
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. This gene encodes a protein with a proline-rich domain. This gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000006251
  • ENSP00000006251
  • ENSG00000186654
  • ENST00000336985
  • ENSP00000337464
  • ENST00000403581
  • ENSP00000384848
  • ENST00000611394
  • ENSP00000480357
  • ENST00000617066
  • ENSP00000479623
  • ENST00000624862
  • ENSP00000485597

Symbol
  • PROTOR1
  • PP610
  • PROTOR1
  • PROTOR-1
  • FLJ20185k
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.82
tissue sample
0.69
disease perturbation
0.62
histone modification site profile
0.62
transcription factor binding site profile
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.31   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.31   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
RICTOR
Tbio
Novelty:  0.00250734
Score:  0.992
Data Source:  STRINGDB
MLST8
Tbio
Novelty:  0.00423122
Score:  0.987
Data Source:  STRINGDB
DEPTOR
Tchem
Novelty:  0.01419675
Score:  0.984
Data Source:  STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
Score:  0.977
Data Source:  STRINGDB
MAPKAP1
Tbio
Novelty:  0.01301743
Score:  0.977
Data Source:  STRINGDB
TTI1
Tbio
Novelty:  0.05516406
Score:  0.97
Data Source:  STRINGDB
SGK1
Tchem
Family:  Kinase
Novelty:  0.00155681
Score:  0.962
Data Source:  STRINGDB
TSC2
Tbio
Novelty:  0.00067416
Score:  0.956
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.953
Data Source:  STRINGDB
TSC1
Tbio
Novelty:  0.00406614
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (79)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
Constitutive Signaling by AKT1 E17K in Cancer
Reactome
Costimulation by the CD28 family
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Constitutive Signaling by AKT1 E17K in Cancer
Costimulation by the CD28 family
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1924714
109270
Rat
RGD:1307954
315189
Pig
proline rich 5
100152201
Chicken
proline rich 5
CGNC:50711
418237
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Pig
proline rich 5
Chicken
proline rich 5
Publication Statistics
PubMed Score 15.31
PubMed score by year
PubTator Score 1.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title