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Tbio
PRPSAP1
Phosphoribosyl pyrophosphate synthase-associated protein 1

Protein Summary
Description
Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000446526
  • ENSP00000414624
  • ENSG00000161542

Symbol
  • PAP39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
virus perturbation
0.85
histone modification site profile
0.8
transcription factor binding site profile
0.78
tissue sample
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.47   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.47   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
PRPSAP2
Tbio
Family:  Enzyme
Novelty:  0.12017454
p_int:  1
Score:  0.869
Data Source:  BioPlex,STRINGDB
IVNS1ABP
Tbio
Novelty:  0.04220812
p_int:  0.999999728
p_ni:  2.72e-7
p_wrong:  1e-9
Score:  0.907
Data Source:  BioPlex,STRINGDB
PRPS1
Tbio
Family:  Kinase
Novelty:  0.01139656
p_int:  0.999999663
p_ni:  3.37e-7
Score:  0.948
Data Source:  BioPlex,STRINGDB
PRPS2
Tbio
Family:  Kinase
Novelty:  0.02472415
p_int:  0.99999921
p_ni:  7.9e-7
Score:  0.959
Data Source:  BioPlex,STRINGDB
C16orf71
Tdark
Novelty:  0.97826087
p_int:  0.900381825
p_ni:  0.099618175
Score:  0.165
Data Source:  BioPlex,STRINGDB
PRPS1L1
Tdark
Family:  Kinase
Novelty:  0.02527534
Score:  0.732
Data Source:  STRINGDB
BORCS8
Tdark
Novelty:  1.62939642
Score:  0.719
Data Source:  STRINGDB
RNF157
Tbio
Novelty:  0.78586559
Score:  0.702
Data Source:  STRINGDB
MXRA7
Tdark
Novelty:  0.20850504
Score:  0.699
Data Source:  STRINGDB
KIAA1211
Tdark
Novelty:  0.83445472
Score:  0.697
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
8
10
98.1
reticulocyte count
7
6
16
97.3
lymphocyte count
3
4
5
95.6
BMI-adjusted waist-hip ratio
3
4
4
85.7
mean reticulocyte volume
1
2
2
79.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
10
98.1
reticulocyte count
16
97.3
lymphocyte count
5
95.6
BMI-adjusted waist-hip ratio
4
85.7
mean reticulocyte volume
2
79.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoribosyl pyrophosphate synthetase associated protein 1
VGNC:12612
739447
Macaque
phosphoribosyl pyrophosphate synthetase associated protein 1
706625
Mouse
MGI:1915013
67763
Rat
RGD:620206
64390
Dog
phosphoribosyl pyrophosphate synthetase associated protein 1
VGNC:45034
608323
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoribosyl pyrophosphate synthetase associated protein 1
Macaque
phosphoribosyl pyrophosphate synthetase associated protein 1
Mouse
Rat
Dog
phosphoribosyl pyrophosphate synthetase associated protein 1
Publication Statistics
PubMed Score 11.47
PubMed score by year
PubTator Score 8.25
PubTator score by year
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Related Publications
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PMID
Year
Title