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Tdark
PRPS1L1
Ribose-phosphate pyrophosphokinase 3

Protein Summary
Description
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. These enzymes convert pyrimidine, purine or pyridine bases to the corresponding ribonucleoside monophosphates. In vitro transcription/translation and site-directed mutagenesis studies indicate that translation of this mRNA initiates exclusively at a non-AUG (ACG) codon. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000638645
  • ENSP00000492583
  • ENSG00000229937

Symbol
  • PRPS3
  • PRPSL
  • PRPS1
  • PRPS3
  • PRPSL
  • PRS-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
cell type or tissue
0.61
protein domain
0.58
tissue sample
0.58
gene perturbation
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.89   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.89   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
PRPSAP2
Tbio
Family:  Enzyme
Novelty:  0.12017454
p_int:  0.999949443
p_ni:  0.000050557
Score:  0.964
Data Source:  BioPlex,STRINGDB
PRPS1
Tbio
Family:  Kinase
Novelty:  0.01139656
p_int:  0.999909084
p_ni:  0.000090915
p_wrong:  1e-9
Score:  0.964
Data Source:  BioPlex,STRINGDB
PPAT
Tclin
Family:  Enzyme
Novelty:  0.01549862
Score:  0.97
Data Source:  STRINGDB
RBKS
Tbio
Family:  Kinase
Novelty:  0.01660806
Score:  0.958
Data Source:  STRINGDB
RPIA
Tbio
Family:  Enzyme
Novelty:  0.00968705
Score:  0.951
Data Source:  STRINGDB
TKTL2
Tbio
Family:  Enzyme
Novelty:  0.0915871
Score:  0.942
Data Source:  STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
Score:  0.937
Data Source:  STRINGDB
UMPS
Tclin
Family:  Enzyme
Novelty:  0.00848756
Score:  0.935
Data Source:  STRINGDB
TKTL1
Tbio
Family:  Enzyme
Novelty:  0.01464511
Score:  0.934
Data Source:  STRINGDB
NUDT5
Tbio
Family:  Enzyme
Novelty:  0.02550535
Score:  0.931
Data Source:  STRINGDB
Pathways (16)
5-Phosphoribose 1-diphosphate biosynthesis (R-HSA-73843)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
5-Phosphoribose 1-diphosphate biosynthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Reactome
Pentose phosphate pathway
Name
Explore in Pharos
Explore in Source
5-Phosphoribose 1-diphosphate biosynthesis
Metabolism
Metabolism of carbohydrates
Pentose phosphate pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
3
3
3
85.2
intelligence
1
1
1
63.6
high density lipoprotein cholesterol measurement
11
4
11
60.4
phospholipids:total lipids ratio
3
2
3
47.6
very low density lipoprotein cholesterol measurement
2
2
2
47.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
3
85.2
intelligence
1
63.6
high density lipoprotein cholesterol measurement
11
60.4
phospholipids:total lipids ratio
3
47.6
very low density lipoprotein cholesterol measurement
2
47.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 49.89
PubMed score by year
PubTator Score 2.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title