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Tbio
PRPF8
Pre-mRNA-processing-splicing factor 8

Protein Summary
Description
Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304992
  • ENSP00000304350
  • ENSG00000174231
  • ENST00000572621
  • ENSP00000460348
  • ENST00000614672
  • ENSP00000479194
  • ENSG00000274442
  • ENST00000634039
  • ENSP00000488611

Symbol
  • PRPC8
  • PRP8
  • RP13
  • HPRP8
  • PRPC8
  • SNRNP220
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
hub protein
1
interacting protein
1
protein domain
1
disease perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.74   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.74   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (455)
CD2BP2
Tbio
Novelty:  0.01440995
p_int:  0.999515873
p_ni:  0.000484127
Score:  0.996
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.992418031
p_ni:  0.007581969
Score:  0.999
Data Source:  BioPlex,STRINGDB
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.987400282
p_ni:  0.012599718
Score:  0.857
Data Source:  BioPlex,STRINGDB
AAR2
Tbio
Novelty:  0.05805748
p_int:  0.98600672
p_ni:  0.01399328
Score:  0.995
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.98448469
p_ni:  0.01551531
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRNP40
Tbio
Novelty:  0.16791896
p_int:  0.984084699
p_ni:  0.015915301
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.98363934
p_ni:  0.01636066
Score:  0.992
Data Source:  BioPlex,STRINGDB
KIAA1143
Tdark
Novelty:  3.96985921
p_int:  0.976116546
p_ni:  0.023883454
Score:  0.653
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.974375967
p_ni:  0.025624033
Data Source:  BioPlex
DDX23
Tbio
Family:  Enzyme
Novelty:  0.03592096
p_int:  0.970550491
p_ni:  0.029449509
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of RNA (R-HSA-8953854)

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (36)
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
6
7
97.9
serum albumin measurement
3
6
7
97.9
sex hormone-binding globulin measurement
6
3
8
96.6
sex hormone-binding globulin measurement
6
3
8
96.6
calcium measurement
1
4
4
94.9
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
7
97.9
serum albumin measurement
7
97.9
sex hormone-binding globulin measurement
8
96.6
sex hormone-binding globulin measurement
8
96.6
calcium measurement
4
94.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pre-mRNA processing factor 8
721238
Mouse
MGI:2179381
192159
Rat
RGD:1305467
287530
Dog
pre-mRNA processing factor 8
VGNC:45030
480651
Horse
pre-mRNA processing factor 8
VGNC:21891
100072388
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pre-mRNA processing factor 8
Mouse
Rat
Dog
pre-mRNA processing factor 8
Horse
pre-mRNA processing factor 8
Publication Statistics
PubMed Score 65.74
PubMed score by year
PubTator Score 86.36
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title