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Tdark
PRPF40B
Pre-mRNA-processing factor 40 homolog B

Protein Summary
Description
May be involved in pre-mRNA splicing. This gene encodes a WW-domain containing protein similar to yeast splicing factor PRP40. This protein has been shown to interact with Huntingtin and methyl CpG binding protein 2 (MeCP2). Alternative splicing results in different transcript variants. [provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261897
  • ENSP00000261897
  • ENSG00000110844
  • ENST00000380281
  • ENSP00000369634

Symbol
  • HYPC
  • HYPC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.75
tissue sample
0.61
transcription factor binding site profile
0.6
cell type or tissue
0.58
transcription factor
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.19   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.19   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
RGS9
Tbio
Novelty:  0.06662559
p_int:  1
Score:  0.943
Data Source:  BioPlex,STRINGDB
GNB5
Tbio
Novelty:  0.0067714
p_int:  0.999973653
p_ni:  0.000026337
p_wrong:  1e-8
Score:  0.825
Data Source:  BioPlex,STRINGDB
RBM25
Tbio
Novelty:  0.05557892
p_int:  0.99964384
p_ni:  0.000356141
p_wrong:  2e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
Score:  0.979
Data Source:  STRINGDB
SF3A1
Tbio
Novelty:  0.03405702
Score:  0.973
Data Source:  STRINGDB
CRNKL1
Tbio
Novelty:  0.10274174
Score:  0.95
Data Source:  STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
Score:  0.941
Data Source:  STRINGDB
LUC7L2
Tbio
Novelty:  0.36989457
Score:  0.939
Data Source:  STRINGDB
SF3B1
Tbio
Novelty:  0.0128965
Score:  0.937
Data Source:  STRINGDB
DDX46
Tbio
Family:  Enzyme
Novelty:  0.02888527
Score:  0.936
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
82.3
2
2
2
75.5
smoking status measurement
2
2
2
75.2
educational attainment
1
1
1
62.3
self reported educational attainment
2
2
2
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
82.3
2
75.5
smoking status measurement
2
75.2
educational attainment
1
62.3
self reported educational attainment
2
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 40 homolog B
VGNC:5547
741984
Macaque
pre-mRNA processing factor 40 homolog B
712580
Mouse
MGI:1925583
54614
Rat
RGD:1565411
363000
Dog
pre-mRNA processing factor 40 homolog B
VGNC:45027
477615
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 40 homolog B
Macaque
pre-mRNA processing factor 40 homolog B
Mouse
Rat
Dog
pre-mRNA processing factor 40 homolog B
Publication Statistics
PubMed Score 26.19
PubMed score by year
PubTator Score 4.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title