You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PRPF4
U4/U6 small nuclear ribonucleoprotein Prp4

Protein Summary
Description
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374198
  • ENSP00000363313
  • ENSG00000136875
  • ENST00000374199
  • ENSP00000363315

Symbol
  • PRP4
  • PRP4
  • RP70
  • HPRP4
  • Prp4p
  • HPRP4P
  • SNRNP60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
protein domain
0.97
virus perturbation
0.97
transcription factor binding site profile
0.9
histone modification site profile
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.52   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.52   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (251)
O43687
Tbio
Family:  Enzyme
Novelty:  0.04114095
p_int:  0.999997749
p_ni:  0.000002251
Data Source:  BioPlex
TUT1
Tbio
Family:  Enzyme
Novelty:  0.01436913
p_int:  0.999993068
p_ni:  0.000006928
p_wrong:  4e-9
Score:  0.857
Data Source:  BioPlex,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.999986877
p_ni:  0.000013123
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MEPCE
Tbio
Novelty:  0.05592081
p_int:  0.999903449
p_ni:  0.000096551
Score:  0.634
Data Source:  BioPlex,STRINGDB
SART3
Tbio
Novelty:  0.02353492
p_int:  0.999800223
p_ni:  0.000199777
Score:  0.892
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.999761792
p_ni:  0.000155668
p_wrong:  0.00008254
Score:  0.958
Data Source:  BioPlex,STRINGDB
GPHN
Tbio
Novelty:  0.0020752
p_int:  0.999713076
p_ni:  0.000286924
Score:  0.215
Data Source:  BioPlex,STRINGDB
N4BP2L2
Tbio
Novelty:  0.24527466
p_int:  0.99955561
p_ni:  0.00044439
Data Source:  BioPlex
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.998529324
p_ni:  0.001470676
Score:  0.994
Data Source:  BioPlex,STRINGDB
ZGPAT
Tbio
Family:  Epigenetic
Novelty:  0.16971298
p_int:  0.995604247
p_ni:  0.004393543
p_wrong:  0.000002211
Score:  0.687
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood lead measurement
1
2
2
86.9
corneal resistance factor
1
1
1
75.4
neutrophil count
1
1
1
59.7
central corneal thickness
1
1
0
2.1
58.9
iron biomarker measurement
1
1
1
58.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood lead measurement
2
86.9
corneal resistance factor
1
75.4
neutrophil count
1
59.7
central corneal thickness
0
2.1
58.9
iron biomarker measurement
1
58.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 4
VGNC:4830
464671
Macaque
pre-mRNA processing factor 4
705934
Mouse
MGI:1917302
70052
Rat
RGD:1311303
298095
Dog
pre-mRNA processing factor 4
VGNC:45025
474807
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 4
Macaque
pre-mRNA processing factor 4
Mouse
Rat
Dog
pre-mRNA processing factor 4
Publication Statistics
PubMed Score 12.52
PubMed score by year
PubTator Score 10.76
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title