Tbio PRPF31 U4/U6 small nuclear ribonucleoprotein Prp31

Protein Summary

Description

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• Q8WWY3
• E7ESA8
• F1T0A4
• F1T0A5
• Q17RB4
• Q8N7F9
• Q9H271
• Q9Y439

Gene Name

• PRPF31

Ensembl ID

• ENST00000321030
• ENSP00000324122
• ENSG00000105618
• ENST00000419967
• ENSP00000405166
• ENST00000613693
• ENSP00000483929
• ENSG00000275885
• ENST00000619391
• ENSP00000480636

Symbol

• PRP31
• RP11
• PRP31
• SNRNP61
• NY-BR-99

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
interacting protein	0.97
histone modification site profile	0.91
co-expressed gene	0.87
transcription factor binding site profile	0.85

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / U4/u6 Small Nuclear Ribonucleoprotein Prp31

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / U4/u6 Small Nuclear Ribonucleoprotein Prp31

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.83   (req: < 5)

Gene RIFs: 61   (req: <= 3)

Antibodies: 260   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.83   (req: >= 5)

Gene RIFs: 61   (req: > 3)

Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (468)

Explore Interacting Targets

1 – 10 of 468

• See Interactions on String-DB

SART3

Tbio

Novelty:  0.02353492

p_int:  0.999997533

p_ni:  0.000002467

Score:  0.963

Data Source:  BioPlex,STRINGDB

DIEXF

Tbio

Novelty:  0.05892659

p_int:  0.999995017

p_ni:  0.000004983

Score:  0.408

Data Source:  BioPlex,STRINGDB

PRPF3

Tbio

Novelty:  0.01600014

p_int:  0.999636532

p_ni:  0.000363468

Score:  0.999

Data Source:  BioPlex,STRINGDB

ZNF622

Tbio

Novelty:  0.26258288

p_int:  0.999040574

p_ni:  0.000202964

p_wrong:  0.000756462

Score:  0.25

Data Source:  BioPlex,STRINGDB

TUT1

Tbio

Family:  Enzyme

Novelty:  0.01436913

p_int:  0.998871885

p_ni:  0.001128113

p_wrong:  3e-9

Score:  0.894

Data Source:  BioPlex,STRINGDB

FBRS

Tbio

Novelty:  0.13646817

p_int:  0.996896104

p_ni:  0.003103895

p_wrong:  1e-9

Data Source:  BioPlex

LSM3

Tbio

Novelty:  0.05044984

p_int:  0.987554801

p_ni:  0.012445199

Score:  0.996

Data Source:  BioPlex,STRINGDB

PRPF4

Tchem

Novelty:  0.08229072

p_int:  0.986937048

p_ni:  0.013062952

Score:  0.999

Data Source:  BioPlex,STRINGDB

LSM7

Tbio

Novelty:  0.09112723

p_int:  0.972414265

p_ni:  0.027585735

Score:  0.996

Data Source:  BioPlex,STRINGDB

MTHFR

Tbio

Family:  Enzyme

Novelty:  0.00018162

p_int:  0.97234802

p_ni:  0.02765198

Score:  0.151

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

KEGG (1)

Metabolism of RNA (R-HSA-8953854)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	mRNA Splicing	188 targets	R-HSA-72172
Reactome	mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
mRNA Splicing	188 targets	R-HSA-72172
mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (5)

Components (10)

Processes (3)

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1 – 5 of 5

GO Term	Evidence	Assigned by
ribonucleoprotein complex binding	Inferred from Direct Assay (IDA)	MGI
U4 snRNA binding	Inferred from Direct Assay (IDA)	GO_Central
U4atac snRNA binding	Inferred from Direct Assay (IDA)	UniProtKB
snRNP binding	Inferred from Physical Interaction (IPI)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (138)

Items per page:

5

1 – 5 of 138

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	ENSG00000275885	2	3	3	18.1	97.7
alkaline phosphatase measurement	EFO_0004533	ENSG00000105618	2	3	3	18.1	97.7
blood metabolite measurement	EFO_0005664	ENSG00000105618	2	2	2		89.9
blood metabolite measurement	EFO_0005664	ENSG00000275885	2	2	2		89.9
phosphatidylinositol measurement	EFO_0010230	ENSG00000275885	1	1	3		78.4

Items per page:

5

1 – 5 of 138

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	3	18.1	97.7
alkaline phosphatase measurement	EFO_0004533	3	18.1	97.7
blood metabolite measurement	EFO_0005664	2		89.9
blood metabolite measurement	EFO_0005664	2		89.9
phosphatidylinositol measurement	EFO_0010230	3		78.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Direct protein sequencing
Disease mutation
Isopeptide bond
mRNA processing
mRNA splicing

GWAS Trait Find Similar Targets

No Header	No Header
adiponectin measurement
alcoholic liver cirrhosis
alkaline phosphatase measurement
amino acid measurement
antioxidant measurement
arm span
asparaginase hypersensitivity
aspartate aminotransferase measurement
birth weight
blood metabolite measurement

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
homeostasis/metabolism phenotype
mortality/aging
pigmentation phenotype
skeleton phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pre-mRNA processing factor 31	VGNC:12068	107969799
Macaque	pre-mRNA processing factor 31		720567
Mouse	pre-mRNA processing factor 31	MGI:1916238	68988
Rat	pre-mRNA processing factor 31	RGD:1305832	292536
Dog	pre-mRNA processing factor 31	VGNC:45021	476389

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pre-mRNA processing factor 31
Macaque	pre-mRNA processing factor 31
Mouse	pre-mRNA processing factor 31
Rat	pre-mRNA processing factor 31
Dog	pre-mRNA processing factor 31

Publication Statistics

PubMed Score 110.83

PubMed score by year

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PubTator Score 238.48

PubTator score by year

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Related Publications

Text Mined References (91)

GeneRif Annotations (61)

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PMID	Year	Title