PRPF31
U4/U6 small nuclear ribonucleoprotein Prp31
Protein Summary
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009]
- ENST00000321030
- ENSP00000324122
- ENSG00000105618
- ENST00000419967
- ENSP00000405166
- ENST00000613693
- ENSP00000483929
- ENSG00000275885
- ENST00000619391
- ENSP00000480636
- PRP31
- RP11
- PRP31
- SNRNP61
- NY-BR-99
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.97 | ||
interacting protein | 0.97 | ||
histone modification site profile | 0.91 | ||
co-expressed gene | 0.87 | ||
transcription factor binding site profile | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 119.28 (req: < 5)
Gene RIFs: 61 (req: <= 3)
Antibodies: 260 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 119.28 (req: >= 5)
Gene RIFs: 61 (req: > 3)
Antibodies: 260 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0