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Tbio
PRPF31
U4/U6 small nuclear ribonucleoprotein Prp31

Protein Summary
Description
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321030
  • ENSP00000324122
  • ENSG00000105618
  • ENST00000419967
  • ENSP00000405166
  • ENST00000613693
  • ENSP00000483929
  • ENSG00000275885
  • ENST00000619391
  • ENSP00000480636

Symbol
  • PRP31
  • RP11
  • PRP31
  • SNRNP61
  • NY-BR-99
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
interacting protein
0.97
histone modification site profile
0.91
co-expressed gene
0.87
transcription factor binding site profile
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.83   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.83   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (468)
SART3
Tbio
Novelty:  0.02353492
p_int:  0.999997533
p_ni:  0.000002467
Score:  0.963
Data Source:  BioPlex,STRINGDB
DIEXF
Tbio
Novelty:  0.05892659
p_int:  0.999995017
p_ni:  0.000004983
Score:  0.408
Data Source:  BioPlex,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.999636532
p_ni:  0.000363468
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZNF622
Tbio
Novelty:  0.26258288
p_int:  0.999040574
p_ni:  0.000202964
p_wrong:  0.000756462
Score:  0.25
Data Source:  BioPlex,STRINGDB
TUT1
Tbio
Family:  Enzyme
Novelty:  0.01436913
p_int:  0.998871885
p_ni:  0.001128113
p_wrong:  3e-9
Score:  0.894
Data Source:  BioPlex,STRINGDB
FBRS
Tbio
Novelty:  0.13646817
p_int:  0.996896104
p_ni:  0.003103895
p_wrong:  1e-9
Data Source:  BioPlex
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.987554801
p_ni:  0.012445199
Score:  0.996
Data Source:  BioPlex,STRINGDB
PRPF4
Tchem
Novelty:  0.08229072
p_int:  0.986937048
p_ni:  0.013062952
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM7
Tbio
Novelty:  0.09112723
p_int:  0.972414265
p_ni:  0.027585735
Score:  0.996
Data Source:  BioPlex,STRINGDB
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
p_int:  0.97234802
p_ni:  0.02765198
Score:  0.151
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (138)
Items per page:
1 – 5 of 138
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
3
3
18.1
97.7
alkaline phosphatase measurement
2
3
3
18.1
97.7
blood metabolite measurement
2
2
2
89.9
blood metabolite measurement
2
2
2
89.9
phosphatidylinositol measurement
1
1
3
78.4
Items per page:
1 – 5 of 138
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
18.1
97.7
alkaline phosphatase measurement
3
18.1
97.7
blood metabolite measurement
2
89.9
blood metabolite measurement
2
89.9
phosphatidylinositol measurement
3
78.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 31
VGNC:12068
107969799
Macaque
pre-mRNA processing factor 31
720567
Mouse
MGI:1916238
68988
Rat
RGD:1305832
292536
Dog
pre-mRNA processing factor 31
VGNC:45021
476389
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 31
Macaque
pre-mRNA processing factor 31
Mouse
Rat
Dog
pre-mRNA processing factor 31
Publication Statistics
PubMed Score 110.83
PubMed score by year
PubTator Score 238.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title