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Tbio
PRPF19
Pre-mRNA-processing factor 19

Protein Summary
Description
Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DD ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227524
  • ENSP00000227524
  • ENSG00000110107

Symbol
  • NMP200
  • PRP19
  • SNEV
  • PSO4
  • SNEV
  • PRP19
  • UBOX4
  • hPSO4
  • NMP200
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
kinase perturbation
0.98
disease perturbation
0.96
biological process
0.91
hub protein
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.71   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.71   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (543)
KNSTRN
Tbio
Novelty:  0.05283444
p_int:  0.999999944
p_ni:  5.5e-8
Score:  0.603
Data Source:  BioPlex,STRINGDB
GCC1
Tbio
Novelty:  0.0844824
p_int:  0.999999885
p_ni:  1.15e-7
Score:  0.175
Data Source:  BioPlex,STRINGDB
YJU2
Tdark
Novelty:  0.75647391
p_int:  0.999999329
p_ni:  6.71e-7
Score:  0.975
Data Source:  BioPlex,STRINGDB
SENP6
Tchem
Family:  Enzyme
Novelty:  0.00776149
p_int:  0.999999138
p_ni:  8.62e-7
Score:  0.665
Data Source:  BioPlex,STRINGDB
ZDBF2
Tdark
Novelty:  0.19205154
p_int:  0.999998526
p_ni:  1.1e-7
p_wrong:  0.000001364
Data Source:  BioPlex
GPATCH1
Tdark
Novelty:  0.93318176
p_int:  0.999992299
p_ni:  0.000007701
Score:  0.946
Data Source:  BioPlex,STRINGDB
CWF19L2
Tdark
Novelty:  0.80210985
p_int:  0.9999877
p_ni:  0.00001226
p_wrong:  4e-8
Score:  0.925
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
p_int:  0.99998705
p_ni:  0.00001295
Score:  0.999
Data Source:  BioPlex,STRINGDB
PLRG1
Tbio
Novelty:  0.05163655
p_int:  0.999975348
p_ni:  0.000024652
Score:  0.999
Data Source:  BioPlex,STRINGDB
AQR
Tbio
Novelty:  0.00434312
p_int:  0.999974965
p_ni:  0.000025035
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
DNA Repair (R-HSA-73894)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Dual incision in TC-NER
Reactome
Formation of TC-NER Pre-Incision Complex
Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
DNA Repair
Dual incision in TC-NER
Formation of TC-NER Pre-Incision Complex
Gap-filling DNA repair synthesis and ligation in TC-NER
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin L1 measurement
1
1
1
77.3
1
1
0
1.2
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin L1 measurement
1
77.3
0
1.2
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 19
VGNC:1039
451228
Macaque
pre-mRNA processing factor 19
696170
Mouse
MGI:106247
28000
Rat
RGD:708496
246216
Dog
pre-mRNA processing factor 19
VGNC:45019
611552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 19
Macaque
pre-mRNA processing factor 19
Mouse
Rat
Dog
pre-mRNA processing factor 19
Publication Statistics
PubMed Score 68.71
PubMed score by year
PubTator Score 62.75
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title