You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PROP1
Homeobox protein prophet of Pit-1

Protein Summary
Description
Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes. This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308304
  • ENSP00000311290
  • ENSG00000175325

Symbol
  • CPHD2
  • PROP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
cell type or tissue
0.72
biological process
0.66
microRNA
0.62
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.92   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.92   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
POU1F1
Tbio
Family:  TF
Novelty:  0.0052029
Score:  0.924
Data Source:  STRINGDB
GHRHR
Tclin
Family:  GPCR
Novelty:  0.00637611
Score:  0.716
Data Source:  STRINGDB
TBX19
Tbio
Family:  TF
Novelty:  0.01599679
Score:  0.696
Data Source:  STRINGDB
PRL
Tbio
Novelty:  0.0000905
Score:  0.677
Data Source:  STRINGDB
SOX3
Tbio
Family:  TF
Novelty:  0.00280653
Score:  0.653
Data Source:  STRINGDB
NOTCH2
Tchem
Novelty:  0.00195617
Score:  0.588
Data Source:  STRINGDB
AES
Tbio
Novelty:  0.00818499
Score:  0.586
Data Source:  STRINGDB
ZNF354C
Tdark
Family:  TF
Novelty:  0.09978239
Score:  0.585
Data Source:  STRINGDB
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
Score:  0.581
Data Source:  STRINGDB
GHRH
Tbio
Novelty:  0.00058152
Score:  0.576
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PROP paired-like homeobox 1
VGNC:14160
471762
Mouse
MGI:109330
19127
Rat
RGD:628759
266738
Dog
PROP paired-like homeobox 1
VGNC:45014
474647
Horse
PROP paired-like homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9455]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PROP paired-like homeobox 1
Mouse
Rat
Dog
PROP paired-like homeobox 1
Horse
PROP paired-like homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9455]
Publication Statistics
PubMed Score 206.92
PubMed score by year
PubTator Score 284.31
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title