Tchem PROKR1 Prokineticin receptor 1

Protein Summary

Description

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy. This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q8TCW9
• A5JUU2
• Q53QT9
• Q8NFJ7
• PK-R1

Gene Name

• PROKR1

Ensembl ID

• ENST00000303786
• ENSP00000303775
• ENSG00000169618

Symbol

• GPR73
• PKR1
• ZAQ
• PKR1
• GPR73
• PK-R1
• GPR73a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.71
cell line	0.49
PubMedID	0.48
ligand (protein)	0.46
chemical	0.45

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Prokineticin Receptor 1

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Prokineticin Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.31   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 35   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.31   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0