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Tbio
PROK2
Prokineticin-2

Protein Summary
Description
May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle. This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295619
  • ENSP00000295619
  • ENSG00000163421
  • ENST00000353065
  • ENSP00000295618

Symbol
  • BV8
  • BV8
  • HH4
  • PK2
  • KAL4
  • MIT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.91
biological process
0.82
PubMedID
0.69
tissue sample
0.68
tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.38   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.38   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (215)
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.997476265
p_ni:  0.002523735
Data Source:  BioPlex
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.99614486
p_ni:  0.001022887
p_wrong:  0.002832253
Data Source:  BioPlex
CPE
Tbio
Family:  Enzyme
Novelty:  0.00197792
p_int:  0.988632457
p_ni:  0.011300302
p_wrong:  0.000067241
Data Source:  BioPlex
LRP1B
Tbio
Novelty:  0.01443405
p_int:  0.988076731
p_ni:  0.011923269
Data Source:  BioPlex
LENG8
Tdark
Novelty:  0.66682078
p_int:  0.9816401
p_ni:  0.018068935
p_wrong:  0.000290965
Data Source:  BioPlex
POF1B
Tbio
Novelty:  0.1232792
p_int:  0.831178975
p_ni:  0.168821025
Data Source:  BioPlex
SORL1
Tbio
Novelty:  0.00380895
p_int:  0.82364722
p_ni:  0.17635278
Data Source:  BioPlex
APP
Tchem
Novelty:  0.00008964
p_int:  0.784552972
p_ni:  0.215447028
Score:  0.901
Data Source:  BioPlex,STRINGDB
PROKR2
Tchem
Family:  GPCR
Novelty:  0.01400881
Score:  0.991
Data Source:  Reactome,STRINGDB
GNRHR
Tclin
Family:  GPCR
Novelty:  0.00203671
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (140)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
3
87.5
monocyte count
2
2
2
77.6
mosaic loss of chromosome Y measurement
2
1
2
76.5
granulocyte percentage of myeloid white cells
1
1
1
50.6
apolipoprotein A 1 measurement
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
87.5
monocyte count
2
77.6
mosaic loss of chromosome Y measurement
2
76.5
granulocyte percentage of myeloid white cells
1
50.6
apolipoprotein A 1 measurement
1
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prokineticin 2
VGNC:2524
736902
Macaque
prokineticin 2
694450
Mouse
MGI:1354178
50501
Rat
RGD:620280
192206
Cow
prokineticin 2
VGNC:33362
387602
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prokineticin 2
Macaque
prokineticin 2
Mouse
Rat
Cow
prokineticin 2
Publication Statistics
PubMed Score 227.38
PubMed score by year
PubTator Score 167.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title