Protein Summary
May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle. This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000295619
- ENSP00000295619
- ENSG00000163421
- ENST00000353065
- ENSP00000295618
- BV8
- BV8
- HH4
- PK2
- KAL4
- MIT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.91 | ||
biological process | 0.82 | ||
PubMedID | 0.69 | ||
tissue sample | 0.68 | ||
tissue | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.38 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 189 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.38 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 189 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (215)
ADGRV1
Family: GPCR
Novelty: 0.01398129
p_int: 0.997476265
p_ni: 0.002523735
Data Source: BioPlex
VWDE
Novelty: 0.37298162
p_int: 0.99614486
p_ni: 0.001022887
p_wrong: 0.002832253
Data Source: BioPlex
CPE
Family: Enzyme
Novelty: 0.00197792
p_int: 0.988632457
p_ni: 0.011300302
p_wrong: 0.000067241
Data Source: BioPlex
LENG8
Novelty: 0.66682078
p_int: 0.9816401
p_ni: 0.018068935
p_wrong: 0.000290965
Data Source: BioPlex
APP
Novelty: 0.00008964
p_int: 0.784552972
p_ni: 0.215447028
Score: 0.901
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (140)
Reactome (7)
WikiPathways (133)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (1)
Components (2)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 2 | 3 | 87.5 | |||||
monocyte count | 2 | 2 | 2 | 77.6 | |||||
mosaic loss of chromosome Y measurement | 2 | 1 | 2 | 76.5 | |||||
granulocyte percentage of myeloid white cells | 1 | 1 | 1 | 50.6 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 45.7 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 3 | 87.5 | |||||
monocyte count | 2 | 77.6 | |||||
mosaic loss of chromosome Y measurement | 2 | 76.5 | |||||
granulocyte percentage of myeloid white cells | 1 | 50.6 | |||||
apolipoprotein A 1 measurement | 1 | 45.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | prokineticin 2 | VGNC:2524 | 736902 | |||||
Macaque | prokineticin 2 | 694450 | ||||||
Mouse | MGI:1354178 | 50501 | ||||||
Rat | RGD:620280 | 192206 | ||||||
Cow | prokineticin 2 | VGNC:33362 | 387602 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | prokineticin 2 | |||||
Macaque | prokineticin 2 | |||||
Mouse | ||||||
Rat | ||||||
Cow | prokineticin 2 | |||||
Publication Statistics
PubMed Score 227.38
PubMed score by year
PubTator Score 167.15
PubTator score by year
Related Publications
Text Mined References (47)
GeneRif Annotations (34)
Items per page:
0 of 0
PMID | Year | Title |
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