Tbio PROK2 Prokineticin-2

Protein Summary

Description

May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle. This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9HC23
• Q53Z79
• Q6ISR0
• PK2

Gene Name

• PROK2

Ensembl ID

• ENST00000295619
• ENSP00000295619
• ENSG00000163421
• ENST00000353065
• ENSP00000295618

Symbol

• BV8
• BV8
• HH4
• PK2
• KAL4
• MIT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.91
biological process	0.82
PubMedID	0.69
tissue sample	0.68
tissue	0.62

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Prokineticin-2

DTO Classes

Protein / Signaling / Hormone / Prokineticin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 292.6   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 189   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 292.6   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0