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Tbio
PRODH
Proline dehydrogenase 1, mitochondrial

Protein Summary
Description
Converts proline to delta-1-pyrroline-5-carboxylate. This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357068
  • ENSP00000349577
  • ENSG00000100033

Symbol
  • PIG6
  • POX2
  • PRODH2
  • POX
  • PIG6
  • HSPOX2
  • PRODH1
  • PRODH2
  • TP53I6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.72
cellular component
0.7
disease
0.61
transcription factor perturbation
0.61
molecular function
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.25   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.25   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
SLC23A3
Tdark
Family:  Transporter
Novelty:  0.26061161
p_int:  0.999999959
p_ni:  4.1e-8
Score:  0.494
Data Source:  BioPlex,STRINGDB
BRAP
Tbio
Novelty:  0.0285957
p_int:  0.999944792
p_ni:  0.000055202
p_wrong:  6e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.961261992
p_ni:  0.038738008
Score:  0.19
Data Source:  BioPlex,STRINGDB
HSPA6
Tbio
Novelty:  0.00654285
p_int:  0.954077385
p_ni:  0.045922615
Score:  0.234
Data Source:  BioPlex,STRINGDB
HSPA2
Tchem
Novelty:  0.01696667
p_int:  0.943750447
p_ni:  0.056249553
Score:  0.572
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.788857413
p_ni:  0.211142587
Data Source:  BioPlex
ALDH4A1
Tbio
Family:  Enzyme
Novelty:  0.01316227
Score:  0.94
Data Source:  STRINGDB
ALDH18A1
Tbio
Family:  Enzyme
Novelty:  0.00301673
Score:  0.933
Data Source:  STRINGDB
PYCR1
Tbio
Family:  Enzyme
Novelty:  0.00220832
Score:  0.856
Data Source:  STRINGDB
OAT
Tchem
Family:  Enzyme
Novelty:  0.00125611
Score:  0.85
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Proline catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Proline catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
3
4
7
97.2
blood metabolite measurement
3
3
4
96.9
metabolite measurement
2
2
2
93.8
serum metabolite measurement
2
2
2
85.5
proline measurement
1
1
1
84.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
7
97.2
blood metabolite measurement
4
96.9
metabolite measurement
2
93.8
serum metabolite measurement
2
85.5
proline measurement
1
84.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97770
19125
Rat
RGD:1590932
680409
Horse
proline dehydrogenase 1, mitochondrial
100050480
Chicken
proline dehydrogenase 1
CGNC:56244
770734
Xenopus
proline dehydrogenase (oxidase) 1
XB-GENE-5866533
100494891
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
proline dehydrogenase 1, mitochondrial
Chicken
proline dehydrogenase 1
Xenopus
proline dehydrogenase (oxidase) 1
Publication Statistics
PubMed Score 212.25
PubMed score by year
PubTator Score 123.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title