You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PROC
Vitamin K-dependent protein C

Protein Summary
Description
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845). This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234071
  • ENSP00000234071
  • ENSG00000115718

Symbol
  • PC
  • APC
  • PROC1
  • THPH3
  • THPH4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological term
0.99
gene perturbation
0.84
cell type or tissue
0.7
chemical
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.35   (req: < 5)
Gene RIFs: 257   (req: <= 3)
Antibodies: 670   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.35   (req: >= 5)
Gene RIFs: 257   (req: > 3)
Antibodies: 670   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 52
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0